Forest and Almirall Announce Positive Results of Clinical Studies for Aclidinium Bromide, a Novel, Long-Acting Anticholinergic f
21 5월 2008 - 12:30AM
PR Newswire (US)
Data Presented at the 2008 International Conference of the American
Thoracic Society TORONTO, May 20 /PRNewswire-FirstCall/ -- Forest
Laboratories, Inc. and Laboratorios Almirall, S.A. today presented
results from four clinical trials assessing the efficacy and safety
of aclidinium bromide, an investigational treatment for chronic
obstructive pulmonary disease (COPD). Data from four preclinical
studies further describing the properties of aclidinium were also
presented at the meeting. (Logo:
http://www.newscom.com/cgi-bin/prnh/20001011/FORESTLOGO )
Presentations included data from a 464-patient randomized,
double-blind, four-week, Phase IIb study that evaluated both the
efficacy and tolerability of once-daily aclidinium (25 mcg, 50 mcg,
100 mcg, 200 mcg or 400 mcg) or placebo in patients with moderate
to severe COPD. An open-label tiotropium (18 mcg) arm was included
as an active control. The study demonstrated aclidinium (200 mcg
and 400 mcg), administered via a multi-dose dry powder inhaler,
significantly increased trough (24-hour) forced expiratory volume
in one second (FEV1) -- an important measure of lung function -- on
Day 29 compared with placebo (p