Service revenues increased by $6.1 million, or 23.0%, from $26.8 million to $32.9 million for the three months ended March 31, 2022, as compared to the same period in 2021. This increase was driven by strong customer demand for our supply chain solutions provided by Cryoport Systems, CRYOPDP, and CRYOGENE.
Product revenues decreased $7.1 million, or 26.9%, from $26.5 million to $19.4 million for the three months ended March 31, 2022, as a result of the New Prague Fire that led to approximately $9.4 million in revenue loss for the quarter. Product revenues consists primarily of revenue from our portfolio of cryogenic stainless-steel freezers, aluminum dewars and related ancillary equipment used in the storage and transport of life sciences commodities, which includes the rapidly growing Cell and Gene Therapy market through a global network of distributors and direct client relationships.
Revenues by market
Revenue from the biopharma/pharma market increased $0.6 million, or 1.5%, from $42.4 million to $43.0 million for the three months ended March 31, 2022, as compared to the same period in 2021. This increase was driven by revenue growth from the support of global clinical trials and commercially launched therapies as well as general demand for our logistics and biostorage services, partially offset by the impact of the New Prague Fire of approximately $6.7 million. We now support 609 clinical trials, of which 477 trials are in the Americas, 99 are in EMEA and 33 are in APAC, compared to 543 clinical trials supported as of March 31, 2021 (429 in the Americas, 86 in EMEA and 28 in APAC). The number of Phase III clinical trials supported increased to 81 trials as of March 31, 2022, of which 57 are in the Americas, 22 are in EMEA, and 2 are in APAC. This compares to 69 Phase III trials (49 in the Americas, 19 in EMEA and 1 in APAC) supported as of March 31, 2021. The activity in the clinical trial space, particularly in the Cell and Gene Therapy market is expected to drive future revenue growth as these clinical trials advance and resulting therapies are commercialized on a global basis.
Our revenue from the animal health market decreased $2.2 million, or 24.5%, from $9.0 million to $6.8 million for the three months ended March 31, 2022, as compared to the same period in 2021. This decrease was due to the New Prague Fire which impacted the revenue for the animal health market by approximately $2.4 million. This New Prague manufacturing facility has ramped back up to full production by the end of March 2022.
Revenues in the reproductive medicine market increased $0.6 million, or 31.8%, from 1.9 million to $2.5 million for the three months ended March 31, 2022, as compared to the same period in 2021. This increase was driven by strong demand for our CryoStork® logistics solution and cryogenic shippers, partially offset by the impact of the New Prague Fire of approximately $0.3 million.
Gross margin and cost of revenues. Gross margin for the three months ended March 31, 2022 was 42.7% of total revenues, as compared to 46.1% of total revenues for the three months ended March 31, 2021. The decrease was primarily a result of increased costs due to global supply chain constraints. Cost of total revenues increased $1.2 million to $30.0 million for the three months ended March 31, 2022, as compared to $28.7 million in the same period in 2021.
Gross margin for our service revenues was 43.1% of service revenues, as compared to 41.9% of service revenues for the three months ended March 31, 2021. Our cost of revenues is primarily comprised of freight charges, payroll and associated expenses related to our global logistics and supply chain centers, depreciation expenses of our Cryoport Express® Shippers and supplies and consumables used for our solutions.
Gross margin for our product revenues was 42.0% of product revenues, as compared to 50.3% of product revenues for the three months ended March 31, 2021. The decrease was a result of increased costs as a result of global supply chain constraints. Product revenues, related cost of revenues and resulting gross margins were primarily driven by our MVE Biological Solutions business. Our cost of product revenues were primarily comprised of materials, direct and indirect labor, inbound freight charges, purchasing and receiving, inspection, and distribution and warehousing of inventory. In addition, shop supplies, facility maintenance costs and depreciation expense for assets used in the manufacturing process were included in cost of product revenues.
Selling, general and administrative expenses. Selling, general and administrative (“SG&A”) expenses include the costs associated with selling our products and services and costs required to support our marketing efforts including legal, accounting, patent, shareholder services, amortization of intangible assets and other administrative functions.
For the first quarter of 2022, SG&A expenses increased by $5.2 million, or 24.5% as compared to the first quarter of 2021. This increase is driven by the further build out of our competencies and infrastructure to support the continuing scaling of our business and demand for Cryoport’s systems and solutions, such as the two new global supply chain centers in Houston, Texas and Morris Plains,