A Food and Drug Administration panel Wednesday backed a proposed diabetes drug being developed by Bristol-Myers Squibb Co. (BMY) and AstraZeneca PLC (AZN), saying the product doesn't appear to increase the risks of heart attacks and strokes.

The panel of outside medical experts was called on by the FDA to discuss whether data submitted in favor of the drug, saxagliptin, was enough to rule out an "unacceptable excess cardiovascular risk relative to competitors." Specifically, the panel voted 10 to 2 on a question that asked if there was enough evidence to show saxagliptin didn't carry excess cardiovascular risk, and effectively amounts to a recommendation that the FDA approve the drug. The agency isn't bound by panel decisions but usually follows its panels' advice.

The FDA's heightened concern about cardiovascular side effects was prompted in part by a research paper published in 2007 linking GlaxoSmithKline PLC's (GSK) widely used Avandia to an increased risk of heart attack. The agency toughened regulatory approval guidelines for type 2 diabetes drugs in December. Applications for saxagliptin, as well as Novo Nordisk A/S's (NVO) liraglutide, were submitted before the new guidelines were issued.

But the agency still required the companies to conduct cardiovascular risk assessment of both products and then sought the advice of medical experts on its Endocrinologic and Metabolic Advisory Committee about whether the analysis was sufficient given that clinical studies were completed before the agency changed its guidelines.

If approved, saxagliptin would be sold with the brand name Onglyza. The FDA could make a final decision by the end of the month.

-By Jennifer Corbett Dooren, Dow Jones Newswires; 202-862-9294; jennifer.corbett@dowjones.com