Acadia Pharmaceuticals Announces Launch of Magnolia's Guide to Adventuring: A Groundbreaking Documentary Series Aiming to Raise Disease Awareness and Redefine Perceptions of Rett Syndrome
15 5월 2024 - 10:05PM
Business Wire
— Video series created by Rett caregiver and
award-winning TV producer, AJ Tesler, and family, showcases the
adapted adventures of families living with Rett syndrome
— Documentary series to be showcased on Rett
Revealed, a website designed to explain and highlight life with
Rett syndrome
Acadia Pharmaceuticals Inc. (Nasdaq: ACAD) today announced the
launch of Magnolia’s Guide to Adventuring, a new, 10-part,
documentary video series by award-winning TV producer, AJ Tesler,
and his wife, Jenny Tesler, featuring their 13-year-old daughter,
Magnolia, who lives with Rett syndrome. The series follows the
Teslers as they are joined by other Rett families on adaptive
adventures across the U.S., including downhill skiing, ice skating
and horseback riding, to foster greater understanding and awareness
of Rett syndrome while inspiring those impacted by this condition
to be empowered by all the things they can do.
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“We believe it’s crucial to showcase the incredible spirit of
individuals living with Rett syndrome and all the things they are
capable of, despite their symptoms,” said AJ Tesler, Executive
Producer and Director of Magnolia’s Guide to Adventuring. “It’s
been a long journey for our family since Maggie’s Rett diagnosis,
and we’ve learned how to make the most of every day by adapting
adventures that we can enjoy as a family. She inspired us to make
this series as a celebration of the uniqueness of each person and
family affected by Rett syndrome in hopes that we can inspire all
families to create their own adventures.”
“At Acadia we have had the privilege of working closely with the
Rett syndrome community and have learned a lot about the lives of
individuals and families living with this condition. Their journeys
teach us that despite the challenges they may face, they possess
remarkable abilities often unseen at first glance,” said Brendan
Teehan, Executive Vice President, Chief Operating Officer, Head of
Commercial. “We are honored to support the Tesler family in their
work to redefine perceptions and highlight the remarkable abilities
and spirits of individuals with Rett syndrome.”
To watch the first episode of the 10-part series, visit
https://www.rettrevealed.com/adventuring-with-magnolia and follow
Rett Revealed on Facebook and Instagram for updates as additional
episodes become available.
About the Filmmakers: AJ & Jenny Tesler
AJ Tesler is an award-winning television, film, and new media
producer and director who has created thousands of hours of content
for the likes of Netflix, Comedy Central, Lionsgate, MTV and Sony.
When he learned his daughter had Rett syndrome, he was compelled to
do everything in his power to tell her story and raise awareness
for the disease. That's when he and his wife, Jenny, started making
Magnolia's Hope (YouTube Series and Documentary Film) and now,
Magnolia’s Guide to Adventuring. Both AJ and Jenny blog and are
active advocates for Rett syndrome.
About Rett Syndrome
Rett syndrome is a rare, complex, neurodevelopmental disorder
that may occur over four stages and affects approximately 6,000 to
9,000 patients in the U.S., with approximately 5,000 patients
currently diagnosed according to an analysis of healthcare claims
data.1-4 A child with Rett syndrome exhibits an early period of
apparently normal development until six to 18 months, when their
skills seem to slow down or stagnate. This is typically followed by
a duration of regression when the child loses acquired
communication skills and purposeful hand use. The child may then
experience a plateau period in which they show mild recovery in
cognitive interests, but body movements remain severely diminished.
As they age, those living with Rett may continue to experience a
stage of motor deterioration which can last the rest of the
patient’s life.3 Rett syndrome is typically caused by a genetic
mutation on the MECP2 gene.5 In preclinical studies, deficiency in
MeCP2 function has been shown to lead to impairment in synaptic
communication, and the deficits in synaptic function may be
associated with Rett manifestations.5-7
Symptoms of Rett syndrome may also include development of hand
stereotypies, such as hand wringing and clapping, and gait
abnormalities.8 Most Rett patients typically live into adulthood
and require round-the-clock care.2,9
About Acadia Pharmaceuticals
Acadia is advancing breakthroughs in neuroscience to elevate
life. For 30 years we have been working at the forefront of
healthcare to bring vital solutions to people who need them most.
We developed and commercialized treatment options for people living
with hallucinations and delusions associated with Parkinson’s
disease psychosis and Rett syndrome. Our clinical-stage development
efforts are focused on Prader-Willi syndrome, Alzheimer’s disease
psychosis and multiple other programs targeting neuropsychiatric
symptoms in central nervous system disorders. For more information,
visit us at Acadia.com and follow us on LinkedIn and Twitter.
References
1 Acadia Pharmaceuticals Inc., Data on file. RTT US Prevalence.
March 2022. 2 Fu C, Armstrong D, Marsh E, et al. Consensus
guidelines on managing Rett syndrome across the lifespan. BMJ
Paediatrics Open. 2020; 4: 1-14. 3 Kyle SM, Vashi N, Justice MJ.
Rett syndrome: a neurological disorder with metabolic components.
Open Biol. 2018; 8: 170216. 4 Acadia Pharmaceuticals Inc., Data on
file. 5 Amir RE, Van den Veyver IB, Wan M, et al. Rett syndrome is
caused by mutations in X-linked MECP2, encoding methyl-CpG-binding
protein 2. Nat Genet. 1999; 23(2): 185-188. 6 Fukuda T, Itoh M,
Ichikawa T, et al. Delayed maturation of neuronal architecture and
synaptogenesis in cerebral cortex of Mecp2-deficient mice. J
Neuropathol Exp Neurol. 2005; 64(6): 537-544. 7 Asaka Y, Jugloff
DG, Zhang L, et al. Hippocampal synaptic plasticity is impaired in
the Mecp2-null mouse model of Rett syndrome. Neurobiol Dis. 2006;
21(1): 217-227. 8 Neul JL, Kaufmann WE, Glaze DG, et al. Rett
syndrome: revised diagnostic criteria and nomenclature. Ann Neurol.
2010; 68(6): 944-950. 9 Daniel C, Tarquinio DO, Hou W, et al. The
changing face of survival in Rett syndrome and MECP2-related
disorders. Pediatr Neurol. 2015; 53(5): 402-411.
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Investor Contact: Acadia Pharmaceuticals Inc. Al Kildani (858)
261-2872 ir@acadia-pharm.com
Acadia Pharmaceuticals Inc. Jessica Tieszen (858) 261-2950
ir@acadia-pharm.com
Media Contact: Acadia Pharmaceuticals Inc. Deb Kazenelson (818)
395-3043 media@acadia-pharm.com
Acadia Pharmaceuticals (NASDAQ:ACAD)
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