Nash Pharmaceuticals Announces Positive Pre-Clinical Results For Its Lead Compound NP-178 in a New Study for Crohn's Disease
03 12월 2018 - 11:45PM
InvestorsHub NewsWire
Nash
Pharmaceuticals Announces Positive Pre-Clinical Results For Its
Lead Compound NP-178
in a New Study for Crohn’s Disease
VANCOUVER, BC --
December, 03, 2018 -- InvestrosHub NewsWire -- Nash Pharmaceuticals
Inc., a wholly owned subsidiary of Breathtec Biomedical
Inc. (CSE: BTH) (CNSX: BTH)
(FRANKFURT: BTI) (OTCQB: BTHCF) (the
“Company” or “Nash Pharma”) is pleased to announce
that in a recent invivo animal study for Crohn’s disease
(CD), NP-178, its lead compound for the treatment of
ulcerative colitis (UC), performed equivalent to and in some
measurements, better than 5-ASA, a current global standard of care
treatment for inflammatory bowel disease (IBD). A new potential
treatment for CD could lead to an orphan drug designation, which
could help expedite its availability to patients. There are a
number of countries globally, that have an orphan drug program in
place whereby companies that develop drugs for certain rare
diseases enjoy enhanced collaboration with the regulatory
authority, incentives, marketing exclusivity, and improved pricing
and reimbursement.
In addition, the Company announces the discovery of a second
compound, NP-120 that was also active in both of the Company’s UC
and CD in vivo studies. Both NP-178 and NP-120 are
currently used clinically for the treatment of neurological
diseases. The Company believes that NP-178 & NP-120 may
modulate novel targets for IBD and is consistent with the concept
that there may be a connection or pathway between the brain and the
gastro intestinal system that could be modulated for therapeutic
treatment opportunities.
Data from this study demonstrated statistically significant
improvements in multiple measurements over multiple time points
relevant to CD including:
NP-178
- Body weight (p<0.001),
occult positivity (p<0.05), colon weight (p<0.05), colon
length (p<0.001) and the colon weight/length ratio
(p<0.001)
- The drug compared very
favourably to the control, 5-ASA, the current standard of care for
IBD.
- No negative side effects
were observed.
- NP-178 is a repurposed,
orally delivered neurological drug.
NP-120
- Body weight (p<0.01),
colon length (p<0.001) and colon weight/length ratios
(p<0.01)
- The drug compared very
favourably to the control, 5-ASA, the current standard of care for
IBD in both the CD and an earlier UC study
- No negative side effects
were observed.
- NP-120 is a repurposed,
orally delivered neurological drug.
“This additional study not
only validated our original discovery of both NP-178 and NP-120 in
an independent in vivo study for CD, but has also opened
up an exciting new opportunity because CD is an orphan disease,”
said Christopher J. Moreau CEO of Nash Pharma. “We look forward to
updating the market with additional information on these compounds
shortly.”
About IBD
The Global Inflammatory Bowel Diseases (IBD) Drug Market Forecast
2018-2028 Report shows that the global inflammatory bowel diseases
(IBD) drug market is estimated at $6.7B in 2017 and $7.6B in 2023.
Biologic therapies held 57% share of the IBD market in 2017. The
antibiotics segment of the IBD market is estimated to grow at a
CAGR of 6.3% from 2018-2023.
About Nash Pharmaceuticals Inc.
Nash Pharma is a wholly owned subsidiary of Breathtec Biomedical
Inc. Nash Pharma is a clinical stage pharmaceutical
development company focused on drug repurposing in the areas of
non–alcoholic steatohepatitis (NASH), chronic kidney disease (CKD)
and inflammatory bowel disease (IBD). Drug repurposing is the
process of discovering new therapeutic uses for
existing drugs. Repurposing offers several benefits over
traditional drug development including a reduction in investment
and risk, shorter research periods and a longer active patent
life.
For more information, visit https://nashpharmaceuticals.com/.
CONTACT INFORMATION
Christopher J. Moreau
CEO
Nash Pharmaceuticals Inc.
604.398.4175 ext 701
info@breathtechbiomedical.com
investors@breathtecbiomedical.com
www.breathtecbiomedical.com
The CSE does not accept responsibility for the adequacy
or accuracy of this release.
Neither the Canadian Securities Exchange nor its Market
Regulator (as that term is defined in the policies of the Canadian
Securities Exchange) accepts responsibility for the adequacy or
accuracy of this release. The Canadian Securities Exchange has not
in any way passed upon the merits of the proposed transaction and
has neither approved nor disapproved the contents of this press
release.
CAUTIONARY DISCLAIMER STATEMENT: No Securities Exchange has
reviewed nor accepts responsibility for the adequacy or accuracy of
the content of this news release. This news release contains
forward-looking statements relating to product development,
licensing, commercialization and regulatory compliance issues and
other statements that are not historical facts. Forward-looking
statements are often identified by terms such as “will”, “may”,
“should”, “anticipate”, “expects” and similar expressions. All
statements other than statements of historical fact, included in
this release are forward-looking statements that involve risks and
uncertainties. There can be no assurance that such statements will
prove to be accurate and actual results and future events could
differ materially from those anticipated in such statements.
Important factors that could cause actual results to differ
materially from the Company’s expectations include the failure to
satisfy the conditions of the relevant securities exchange(s) and
other risks detailed from time to time in the filings made by the
Company with securities regulations. The reader is cautioned that
assumptions used in the preparation of any forward-looking
information may prove to be incorrect. Events or circumstances may
cause actual results to differ materially from those predicted, as
a result of numerous known and unknown risks, uncertainties, and
other factors, many of which are beyond the control of the Company.
The reader is cautioned not to place undue reliance on any
forward-looking information. Such information, although considered
reasonable by management at the time of preparation, may prove to
be incorrect and actual results may differ materially from those
anticipated. Forward-looking statements contained in this news
release are expressly qualified by this cautionary statement. The
forward-looking statements contained in this news release are made
as of the date of this news release and the Company will update or
revise publicly any of the included forward-looking statements as
expressly required by applicable law.
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