PTP Profile Thera.

RNS Number:7655W
Profile Therapeutics PLC
22 March 2004


Companies Act 1985 ("the Act") - Disclosure of Interests In Shares

In accordance with sections 198 - 202 of the Act (as amended by the Companies 
Act 1989 and the Disclosure of Interestsin Shares (Amendment) Regulations 1993) 
we hereby notify you of a change in the interest of 3i Group plc in the share 
capital of your company which is notifiable under the provisions of the Act and 
which is detailed below:

Registered Holder   Beneficial Owner      Ordinary shares of 2p each

BNY (OCS) Nominees 
Limited a/c 3i plc        3i Group plc                   1,444,117

BNY (OCS) Nominees 
Limited a/c 3iBio         3i Bioscience 
                          Investment Trust plc*          8,072,267


                          Total interest of 3i 
                          Group plc                      9,516,384

3i Holdings plc, 3i plc and 3i Investments plc are also interested in the shares 
beneficially owned by 3i Bioscience Investment Trust plc.





                      This information is provided by RNS
            The company news service from the London Stock Exchange
END
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