TIDMBNR

RNS Number : 4407U

Burning Rock Biotech Limited

28 March 2023

B urning R ock Reports Fourth Quarter and Full Year 202 2 Financial Results

GUANGZHOU, China, March 28, 2023-Burning Rock Biotech Limited (NASDAQ: BNR and LSE: BNR, the "Company" or "Burning Rock"), a company focused on the application of next generation sequencing (NGS) technology in the field of precision oncology, today reported financial results for the three months and the year ended December 31, 2022.

2022 Business Overview and Recent Updates

   --         Corporate 

o Listed on the Main Market of the London Stock Exchange (the "LSE") by way of a direct listing on November 1, 2022, offering an alternative listing venue in addition to the Nasdaq Global Market.

o Completed profitability-driven organizational optimization.

   --         Early Detection 

o OverC(TM) Multi-Cancer Detection Blood Test (MCDBT) obtained Breakthrough Device Designation of the U.S. Food and Drug Administration (FDA) in January 2023, the third of its kind globally.

o THUNDER study for 6-cancer test released on Annals of Oncology in March, 2023, achieving a comparably high sensitivity of 69.1% and a specificity of 98.9% in detecting six cancers, and showing an impressive performance of ELSA-seq using cfDNA in cancer detection and origin prediction.

o Completed PROMISE study (2,035 participants , 9-cancer test development) in June 2022, continued to carry out PREDICT and PRESCIENT studies (17,000 participants , 22-cancer test development), launched PREVENT study (12,500 subjects, validation) in the second quarter of 2022.

   --         Therapy Selection and Minimal Residual Disease (MRD) 

o Gained NMPA approval for a 9-gene panel, the Company's second NMPA-approved product.

o Presented additional MRD datasets on colorectal and pancreatic cancers at the ASCO Gastrointestinal Cancers Symposium (ASCO GI) in January 2023. "Patient-specific tumor-informed circulating tumor DNA (ctDNA) analysis for molecular residual disease (MRD) detection in surgical patients with stages I-IV colorectal cancer (CRC)" and "Patient-specific tumor-informed circulating tumor DNA (ctDNA) assay predicts cancer recurrence in patients with resected pancreatic cancer".

   --         Pharma Services 

o T otal value of new contracts entered into during 2022 amounted to RMB250 million , representing a 36% increase from 2021.

Fourth Quarter 2022 Financial Results

Revenues were RMB142.2 million (US$20.6 million) for the three months ended December 31, 2022, representing a 3.5% decrease from RMB147.3 million for the same period in 2021.

-- Revenue generated from central laboratory business was RMB72.0 million (US$10.4 million) for the three months ended December 31, 2022, representing a 16.3% decrease from RMB86.0 million for the same period in 2021, primarily attributable to the resurgence of COVID-19 pandemic that resulted in a sharp drop in the number of tests performed.

-- Revenue generated from in-hospital business was RMB42.5 million (US$6.2 million) for the three months ended December 31, 2022, representing a 18.1% decrease from RMB 51.9 million for the same period in 2021 , driven by a decrease of sales volume as af fected by the resurgence of COVID-19 .

-- Revenue generated from pharma research and development services was RMB27.7 million (US$4.0 million) for the three months ended December 31, 2022, representing a 193.2% increase from RMB9.5 million for the same period in 2021, primarily attributable to a further increased testing volume performed for our pharma customers.

Cost of revenues was RMB41.0 million (US$5.9 million) for the three months ended December 31, 2022 , remaining relatively stable compared to RMB42.0 million for the same period in 2021 .

Gross profit was RMB101.3 million (US$14.7 million) for the three months ended December 31, 2022 , representing a 3.9% decrease from RMB105.4 million for the same period in 2021. Gross margin was 71.2% for the three months ended December 31, 2022, compared to 71.5% of the same period in 2021. By channel, gross margin of central laboratory business was 75.7% for the three months ended December 31, 2022, compared to 76.7% during the same period in 2021; gross margin of in-hospital business was 63.5% for the three months ended December 31, 2022, compared to 65.9% during the same period in 2021; gross margin of pharma research and development services was 71.2% for the three months ended December 31, 2022, compared to 55.0% during the same period of 2021, primarily due to an increase in test volume of higher margin projects.

Non-GAAP gross profit, which excludes depreciation and amortization expenses, was RMB110.4 million (US$16.0 million) for the three months ended December 31, 2022 , representing a 2.8% increase from RMB107.4 million for the same period in 2021. Non-GAAP gross margin was 77.6% for the three months ended December 31, 2022, compared to 72.9% for the same period in 2021.

Operating expenses were RMB318.7 million (US$46.2 million) for the three months ended December 31, 2022, representing a 10.9% decrease from RMB 357.5 million for the same period in 2021 . The decrease was primarily driven by budget control measures and headcount reduction to improve the Company's operating efficiency .

-- Research and development expenses were RMB 100.8 million (US$14.6 million) for the three months ended December 31, 2022, representing an 10.6% decrease from RMB 112.7 million for the same period in 2021, primarily due to (i) a decrease in the expenditure for early cancer detection research, and (ii) a decrease in research and development personnel's staff cost , partially offset by an increase in amortized expense on share-based compensation to constantly motivate staff.

-- Selling and marketing expenses were RMB 85.2 million (US$12.3 million) for the three months ended December 31, 2022, representing a 17.5% decrease from RMB 103.2 million for the same period in 2021, primarily due to (i) a decrease in staff cost resulted from the reorganization of the selling department and improvement in operating efficiency; (ii) a decrease in amortized expense on share-based compensation; and (iii) a decrease in advertising and marketing fee.

-- General and administrative expenses were RMB 132.7 million (US$19.2 million) for the three months ended December 31, 2022, representing a 6.3% decrease from RMB141.6 million for the same period in 2021, primarily due to (i) a decrease in general and administrative personnel's staff cost; (ii) a decrease in allowance for credit loss in relation to accounts receivables; and (iii) an increase in depreciation expenses for new buildings.

Net loss was RMB 216.2 million (US$31.4 million) for the three months ended December 31, 2022, compared to RMB251.1 million for the same period in 2021.

Cash, cash equivalents, restricted cash and short-term investments were RMB 925.3 million ( US$ 134.2 million) as of December 31 , 2022.

Full Year 2022 Financial Results

Revenues were RMB 563.2 million (US$81.7 million) for 2022, representing a 10.9% increase from RMB507.9 million for 2021.

-- Revenue generated from central laboratory business was RMB314.8 (US$ 45.6 million) for 2022, remaining relatively stable compared to RMB319.4 million for 2021.

-- Revenue generated from in-hospital business was RMB 175.3 million (US$25.4 million) for 2022, representing a 6.2% increase from RMB165.1 million for 2021, primarily due to (i) increased demand from existing hospitals and (ii) demand from eight new contracted partner hospitals added to the Company's in-hospital channel in 2022.

-- Revenue generated from pharma research and development services was RMB73.2 million (US$10.6 million) for 2022, representing a 212.8% increase from RMB23.4 million for 2021, primarily attributable to increased development and testing services performed for our pharma customers.

Cost of revenues was RMB183.2 million (US$ 26.6 million) for 2022, representing a 27.5% increase from RMB143.7 million for 2021, primarily due to an increase in cost of revenues for our in-hospital business and pharma research and development services.

Gross profit was RMB 380.0 million (US$55.1 million) for 2022, representing a 4.4% increase from RMB364.1 million for 2021. Gross margin decreased to 67.5% for 2022 from 71.7% for 2021.

Non-GAAP gross profit, which excludes depreciation and amortization expenses, was RMB411.0 million (US$59.6 million) for 2022 , representing a 11.6% increase from RMB368.2 million for 2021. Non-GAAP gross margin was 73.0% for 2022, compared to 72.5% for 2021.

Operating expenses were RMB 1,360.4 million (US$197.2 million) for 2022, representing a 17.2% increase from RMB1,161.2 million for 2021.

-- Research and development expenses were RMB 421.9 million (US$61.2 million) for 2022, representing a 14.7% increase from RMB367.9 million for 2021, primarily due to (i) an increase in expenditure for early cancer detection research, (ii) an increase in depreciation expenses for new buildings; and (iii) an increase in amortized expense on share-based compensation.

-- Selling and marketing expenses were RMB370.3 million (US$ 53.7 million) for 2022, representing a 22.2% increase from RMB303.1 million for 2021, primarily due to (i) an increase in staff cost of sales and marketing personnel in anticipation of the commercialization of our early detection products and pharma research and development services; (ii) an increase in conference fee and marketing fees; and (iii) an increase in amortized expense on share-based compensation.

-- General and administrative expenses were RMB 568.3 million (US$82.4 million) for 2022, representing a 15.9% increase from RMB490.3 million for 2021, primarily due to (i) an increase in depreciation expenses for new buildings, and (ii) an increase in allowance for credit loss in relation to accounts receivables; and (iii) an increase amortized expense on share-based compensation.

Net loss was RMB 971.2 million (US$140.8 million) for 2022, compared to RMB796.7 million for 2021.

2023 Financial Guidance

We currently expect our full year 2023 revenues to grow approximately 20% over 2022.

Silicon Valley Bank Event

The Company promptly transferred its cash deposits at Silicon Valley Bank to its accounts with other major financial institutions as a result of the Company's regular risk assessment process. No loss was incurred to such deposits. We maintain bank accounts with a diversified set of financial institutions.

Conference Call Information

Burning Rock will host a conference call to discuss the fourth quarter and full year 2022 financial results at 8:00 a.m. U.S. Eastern Time (8:00 p.m. Hong Kong time) on March 28, 2023.

Please register in advance of the conference using the link provided below and dial in 15 minutes prior to the call, using participant dial-in numbers and unique registrant ID which would be provided upon registering.

PRE-REGISTER LINK: https://register.vevent.com/register/BI1cc3eb383ecf42c6969319f9e9cdd02c .

Additionally, a live and archived webcast of the conference call and presentation slides will also be available on the company's investor relations website at http://ir.brbiotech.com or through link https://edge.media-server.com/mmc/p/tx2a7ju9 .

A replay of the webcast will be available for 12 months via the same link above.

About Burning Rock

Burning Rock Biotech Limited (NASDAQ: BNR and LSE: BNR), whose mission is to guard life via science, focuses on the application of next generation sequencing (NGS) technology in the field of precision oncology. Its business consists of i) NGS-based therapy selection testing for late-stage cancer patients, and ii) cancer early detection, which has moved beyond proof-of-concept R&D into the clinical validation stage.

For more information about Burning Rock, please visit: ir.brbiotech.com.

Safe Harbor Statement

This press release contains forward-looking statements. These statements constitute "forward-looking" statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and as defined in the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "target," "confident" and similar statements. Burning Rock may also make written or oral forward-looking statements in its periodic reports to the SEC, in its annual report to shareholders, in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Statements that are not historical facts, including statements about Burning Rock's beliefs and expectations, are forward-looking statements. Such statements are based upon management's current expectations and current market and operating conditions, and relate to events that involve known or unknown risks, uncertainties and other factors, all of which are difficult to predict and many of which are beyond Burning Rock's control. Forward-looking statements involve risks, uncertainties and other factors that could cause actual results to differ materially from those contained in any such statements. All information provided in this press release is as of the date of this press release, and Burning Rock does not undertake any obligation to update any forward-looking statement as a result of new information, future events or otherwise, except as required under applicable law.

Non-GAAP Measures

In evaluating the business, the company considers and uses non-GAAP measures, such as non-GAAP gross profit and non-GAAP gross margin, as supplemental measures to review and assess operating performance. The presentation of these non-GAAP financial measures is not intended to be considered in isolation or as a substitute for the financial information prepared and presented in accordance with accounting principles generally accepted in the United States of America ("U.S. GAAP"). The company defines non-GAAP gross profit as gross profit excluding depreciation and amortization. The company defines non-GAAP gross margin as gross margin excluding depreciation and amortization.

The company presents these non-GAAP financial measures because they are used by management to evaluate operating performance and formulate business plans. The company believe non-GAAP gross profit and non-GAAP gross margin excluding non-cash impact of depreciation and amortization reflect the company's ongoing business operations in a manner that allows more meaningful period-to-period comparisons.

Contact: IR@brbiotech.com

Selected Operating Data

 
                                                 For the three months ended 
                      -------  --------------------------------------------------------------  -----------  ---------- 
                                          September    December 31,    March 31, 2022    June    September    December 
                                 June        30,                                         30,     30, 2022     31, 2022 
                                  30,       2021                                         2022 
                        March                              2021 
                         31, 
                        2021      2021 
                      -------  -------  -----------  --------------  ----------------  ------  -----------  ---------- 
 Central Laboratory 
  Channel: 
 Number of patients 
  tested                7,716    8,155        7,808           8,235             7,743   8,060        7,989       6,419 
                      -------  -------  -----------  --------------  ----------------  ------  -----------  ---------- 
 Number of ordering 
  physicians(1)         1,082    1,013          920             917               994     767          897         797 
                      -------  -------  -----------  --------------  ----------------  ------  -----------  ---------- 
 Number of ordering 
  hospitals(2)            303      300          287             306               318     264          257         238 
                      -------  -------  -----------  --------------  ----------------  ------  -----------  ---------- 
 
 
(1)  Represents physicians who on average order at least one test from us every month during a 
      relevant period in the central laboratory channel. 
(2)  Represents hospitals whose residing physicians who on average order at least one test from 
      us every month during a relevant period in the central laboratory channel.                                                              A s of 
                      ----------------  -------------------------------------------------------------  -----------  ---------- 
                                                      September 30, 2021    December    March    June    September    December 
                                                                              31,        31,     30,        30,         31, 
                                          June 30,                            2021      2022     2022      2022         2022 
                        March 31, 2021      2021 
                      ----------------  ----------  --------------------  ----------  -------  ------  -----------  ---------- 
       In-hospital 
       Channel: 
       Pipeline 
        partner 
        hospitals(1)                22          22                    24          23       24      25           22          28 
                      ----------------  ----------  --------------------  ----------  -------  ------  -----------  ---------- 
       Contracted 
        partner 
        hospitals(2)                32          34                    34          41       41      43           47          49 
                      ----------------  ----------  --------------------  ----------  -------  ------  -----------  ---------- 
       Total number 
        of partner 
        hospitals                   54          56                    58          64       65      68           69          77 
                      ----------------  ----------  --------------------  ----------  -------  ------  -----------  ---------- 
(1)  Refers to hospitals that are in the process of establishing in-hospital laboratories, laboratory 
      equipment procurement or installation, staff training or pilot testing using the Company's 
      products. 
(2)  Refers to hospitals that have entered into contracts to purchase the Company's products for 
      use on a recurring basis in their respective in-hospital laboratories the Company helped them 
      establish. Kit revenue is generated from contracted hospitals. 
 

Selected Financial Data

 
 
                                                    For the three months ended 
                       ------------  --------------------------------------------------------  -----------  ---------- 
                                                   September    December    March      June      September    December 
                                                      30,                    31,        30,      30, 2022     31, 2022 
                         March 31 ,    June 30,      2021                    2022      2022 
                                                                   31, 
  Revenues                  2021         2021                     2021 
                       ------------  ----------  -----------  ----------  --------  ---------  -----------  ---------- 
                                                        (RMB in thousands) 
 Central laboratory 
  channel                    74,561      79,999       78,817      85,976    74,211     78,597       89,992      71,970 
                       ------------  ----------  -----------  ----------  --------  ---------  -----------  ---------- 
                                                                              48 , 
 In-hospital channel         28,994      40,502       43,714      51,906       957     34,177       49,636      42,526 
                       ------------  ----------  -----------  ----------  --------  ---------  -----------  ---------- 
 Pharma research and 
  development channel         3,068       6,778        4,084       9,463    12,356     18,072       15,003      27,741 
                       ------------  ----------  -----------  ----------  --------  ---------  -----------  ---------- 
 Total revenues             106,623     127,279      126,615     147,345   135,524    130,846      154,631     142,237 
                       ------------  ----------  -----------  ----------  --------  ---------  ----------- 
 
 
                                                       For the three months ended 
                            ------------  ---------------------------------------------------  -----------  ---------- 
                                                     September    December    March     June     September    December 
                                            June        30,         31,        31,       30,        30,         31, 
                              March 31 ,     30,       2021                    2022     2022       2022         2022 
  Gross profit                   2021        2021                   2021 
                            ------------  -------  -----------  ----------  --------  -------  -----------  ---------- 
                                                          (RMB in thousands) 
 Central laboratory 
  channel                         55,212   58,681       58,387      65,985    50,574   57,575       69,991      54,507 
                            ------------  -------  -----------  ----------  --------  -------  ----------- 
 In-hospital channel              20,070   29,426       31,111      34,194    33,396   20,012       31,593      26,999 
                            ------------  -------  -----------  ----------  --------  -------  ----------- 
 Pharma research and 
  development channel              1,658    2,124        2,098       5,200     3,610    5,015        7,010      19,757 
                            ------------  -------  -----------  ----------  --------  -------  ----------- 
 Total gross profit               76,940   90,231       91,596     105,379    87,580   82,602      108,594     101,263 
                            ------------  -------  -----------  ----------  --------  -------  ----------- 
 
 
 
 
 
                                                                           For the three months ended 
                                      ------------  -----------------------------------------------------------------------  -----------  ---------- 
                                                               September    December 31,    March 31, 2022    June 30, 2022    September    December 
                                                      June        30,                                                          30, 2022     31, 2022 
                                        March 31 ,     30,       2021 
  Share-based compensation expenses        2021        2021                     2021 
                                      ------------  -------  -----------  --------------  ----------------  ---------------  -----------  ---------- 
                                                                              (RMB in thousands) 
 Cost of revenues                              339      406          267             492               365              441          481        49 6 
                                      ------------  -------  -----------  --------------  ----------------  ---------------  -----------  ---------- 
 Research and development expenses          22,404   20,825      (9,559)         (4,033)            12,299           11,923       13,978      14,673 
                                      ------------  -------  -----------  --------------  ----------------  ---------------  -----------  ---------- 
                                                                                                                                                2,24 
 Selling and marketing expenses              2,633    2,809        2,044           2,126             1,774            2,158        2,346           7 
                                      ------------  -------  -----------  --------------  ----------------  ---------------  -----------  ---------- 
 General and administrative expenses        59,382   59,369       60,803          62,126            65,715           62,615       61,041      74,232 
                                      ------------  -------  -----------  --------------  ----------------  ---------------  -----------  ---------- 
 Total share-based compensation                                                                                                                91,64 
  expenses                                  84,758   83,409       53,555          60,711            80,153           77,137       77,846           8 
                                      ------------  -------  -----------  --------------  ----------------  ---------------  -----------  ---------- 
 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

(in thousands, except for number of shares and per share data)

 
                                                       For the three months ended 
                  ---------------------------------------------------------------------------------------------------  -----------  ----------- 
                                    June 
                    March 31 ,       30,                    December 31, 
                                                                                                June       September     December     December 
                                               September                                         30,          30,           31,          31, 
                       2021          2021      30, 2021         2021        March 31, 2022      2022          2022         2022         2022 
                  ------------  -----------  -----------  --------------  ----------------  -----------  ------------  -----------  ----------- 
                       RMB          RMB          RMB            RMB              RMB            RMB           RMB          RMB          US$ 
 Revenues              106,623      127,279      126,615         147,345           135,524      130,846       154,631      142,237       20,622 
 Cost of                                                                                       ( 48,244 
  revenues            (29,683)     (37,048)     (35,019)        (41,966)          (47,944)            )      (46,037)     (40,974)      (5,940) 
                  ------------  -----------  -----------  --------------  ----------------  -----------  ------------  -----------  ----------- 
 Gross profit           76,940       90,231       91,596         105,379            87,580       82,602       108,594      101,263       14,682 
 Operating 
 expenses: 
 Research and 
  development 
  expenses            (77,414)    (108,071)     (69,649)       (112,724)         (119,496)     (92,112)     (109,433)    (100,827)     (14,619) 
 Selling and 
  marketing 
  expenses            (55,130)     (68,058)     (76,687)       (103,221)          (89,211)    (105,634)      (90,275)     (85,174)     (12,349) 
 General and 
  administrative 
  expenses           (116,259)    (116,130)    (116,304)       (141,563)         (141,733)    (150,316)     (143,530)    (132,705)     (19,240) 
 Total operating 
  expenses           (248,803)    (292,259)    (262,640)       (357,508)         (350,440)    (348,062)     (343,238)    (318,706)     (46,208) 
 Loss from 
  operations         (171,863)    (202,028)    (171,044)       (252,129)         (262,860)    (265,460)     (234,644)    (217,443)     (31,526) 
 Interest income           787          681          958           1,031             1,832        2,685         2,001        2,838          411 
 Interest 
  expenses               (510)        (565)        (367)            (94)               119         (29)            12            -            - 
 Other income 
  (expense), net           118          433           20           (372)               298          127         (189)         (84)         (12) 
 Foreign 
  exchange gain 
  (loss), net               57        (560)          380           (731)             (777)          624         1,337          365           53 
 Loss before 
  income tax         (171,411)    (202,039)    (170,053)       (252,295)         (261,388)    (262,053)     (231,483)    (214,324)     (31,074) 
 Income tax 
  (expenses) 
  benefits                   -      (1,626)        (424)           1,151                 -         (84)             -      (1,901)        (276) 
                  ------------  -----------  -----------  --------------  ----------------  -----------  ------------  -----------  ----------- 
 Net loss            (171,411)    (203,665)    (170,477)       (251,144)         (261,388)    (262,137)     (231,483)    (216,225)     (31,350) 
                  ============  ===========  ===========  ==============  ================  ===========  ============  ===========  =========== 
 Net loss 
  attributable 
  to Burning 
  Rock Biotech 
  Limited's 
  shareholders       (171,411)    (203,665)    (170,477)       (251,144)         (261,388)    (262,137)     (231,483)    (216,225)     (31,350) 
 Net loss 
  attributable 
  to ordinary 
  shareholders       (171,411)    (203,665)    (170,477)       (251,144)         (261,388)    (262,137)     (231,483)    (216,225)     (31,350) 
 Loss per share 
 for class A and 
 class B 
 ordinary 
 shares: 
 Class A 
  ordinary 
  shares - basic 
  and diluted           (1.65)       (1.96)       (1.64)          (2.40)            (2.50)       (2.50)        (2.23)         2.11         0.31 
 Class B 
  ordinary 
  shares - basic 
  and diluted           (1.65)       (1.96)       (1.64)          (2.40)            (2.50)       (2.50)        (2.23)         2.11         0.31 
 Weighted 
 average shares 
 outstanding 
 used in loss 
 per share 
 computation: 
 Class A 
  ordinary 
  shares - basic 
  and diluted       86,721,263   86,764,260   86,908,975      87,128,297        87,179,752   87,532,539    86,585,322   85,051,882   85,051,882 
 Class B 
  ordinary 
  shares - basic 
  and diluted       17,324,848   17,324,848   17,324,848      17,324,848        17,324,848   17,324,848    17,324,848   17,324,848   17,324,848 
 Other 
 comprehensive 
 income (loss), 
 net of tax of 
 nil: 
 Foreign 
  currency 
  translation 
  adjustments           14,080     (34,980)        6,146        (24,726)           (3,065)       29,715        20,646      (5,950)        (863) 
 Total 
  comprehensive 
  loss               (157,331)    (238,645)    (164,331)       (275,870)         (264,453)    (232,422)     (210,837)    (222,175)     (32,213) 
 Total 
  comprehensive 
  loss 
  attributable 
  to Burning 
  Rock Biotech 
  Limited's 
  shareholders       (157,331)    (238,645)    (164,331)       (275,870)         (264,453)    (232,422)     (210,837)    (222,175)     (32,213) 
 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

(in thousands, except for number of shares and per share data)

 
                                                        For the year ended 
                                            ----------------------------------------- 
                                               December       December      December 
                                                 3 1 ,          3 1 ,         3 1 , 
                                                 202 1           2022          2022 
                                            -------------  -------------  ----------- 
                                                 RMB            RMB           US$ 
 Revenues                                         507,862        563,238       81,662 
                                                               (183, 199     (26, 5 6 
 Cost of revenues                               (143,716)              )          1 ) 
                                            -------------  -------------  ----------- 
 Gross profit                                     364,146     3 80 , 039    5 5 , 101 
 Operating expenses: 
 Research and development expenses              (367,858)      (421,868)     (61,165) 
 Selling and marketing expenses                 (303,096)      (370,294)     (53,688) 
 General and administrative expenses            (490,256)      (568,284)     (82,393) 
                                              (1,161,210)    (1,360,446) 
  Total operating expenses                      (797,064)                   (197,246) 
 Loss from operations                                          (980,407)    (142,145) 
 Interest income                                    3,457          9,356        1,356 
 Interest expenses                                (1,536)            102           15 
 Other income, net                                    199            152           22 
 Foreign exchange loss, net                         (854)          1,549          225 
 Loss before income tax                         (795,798)      (969,248)    (140,527) 
 Income tax expenses                                (899)        (1,985)        (288) 
                                            -------------  -------------  ----------- 
                                                                 (97 1 ,      (14 0 , 
 Net loss                                       (796,697)          233 )        815 ) 
                                            =============  =============  =========== 
 Net loss attributable to Burning                                (97 1 ,      (14 0 , 
  Rock Biotech Limited's shareholders           (796,697)          233 )        815 ) 
 Net loss attributable to ordinary                               (97 1 ,     ( 14 0 , 
  shareholders                                  (796,697)          233 )        815 ) 
 Loss per share for class A and 
  class B ordinary shares: 
 Class A ordinary shares - basic 
  and diluted                                     (7.65 )         (9.35)       (1.36) 
 Class B ordinary shares - basic 
  and diluted                                     (7.65 )         (9.35)       (1.36) 
 Weighted average shares outstanding 
  used in loss per share computation: 
 Class A ordinary shares - basic 
  and diluted                                  86,883,011     86,584,100   86,584,100 
 Class B ordinary shares - basic 
  and diluted                                  17,324,848     17,324,848   17,324,848 
 Other comprehensive income (loss), 
  net of tax of nil: 
 Foreign currency translation adjustments        (39,480)         41,346        5,995 
 Total comprehensive loss                       (836,177)      (929,887)    (134,820) 
 Total comprehensive loss attributable 
  to Burning Rock Biotech Limited's 
  shareholders                                  (836,177)      (929,887)    (134,820) 
                                            =============  =============  =========== 
 

Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets

(In thousands)

 
                                                         As of 
                                                        December     December 
                                                           31,         31, 
                                           December 
                                           31, 2021        2022        2022 
                                         -----------  -----------  ---------- 
                                             RMB          RMB          US$ 
 ASSETS 
 Current assets: 
 Cash and cash equivalents                 1,431,317      905,451     131,278 
 Restricted cash                               7,795       19,817       2,873 
 Short-term investments                       63,757            -           - 
 Accounts receivable, net                     92,197      109,954      15,942 
 Contract assets, net                         42,391       41,757       6,054 
 Inventories, net                            123,210      130,321      18,895 
 Prepayments and other current assets, 
  net                                         60,279       51,462       7,462 
 Total current assets                      1,820,946    1,258,762     182,504 
                                         -----------  -----------  ---------- 
 Non-current assets: 
 Equity method investment                        910          690         100 
 Convertible note receivable                       -        5,105         740 
 Property and equipment, net                 325,438      251,829      36,512 
 Operating right-of-use assets                81,007       48,205       6,989 
 Intangible assets, net                        5,150        1,986         288 
 Other non-current assets                     45,136       20,890       3,029 
 Total non-current assets                    457,641      328,705      47,658 
                                         -----------  -----------  ---------- 
 TOTAL ASSETS                              2,278,587    1,587,467     230,162 
                                         ===========  ===========  ========== 
 

Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets (Continued)

(in thousands)

 
                                                           As of 
                                                           December     December 
                                                             31,           31, 
                                             December 
                                             31, 2021        2022          2022 
                                          ------------  ------------  ----------- 
                                               RMB           RMB          US$ 
 LIABILITIES AND SHAREHOLDERS' EQUITY 
 Current liabilities : 
 Accounts payable                               63,080        50,947        7,387 
 Deferred revenue                              142,871       147,633       21,405 
 Accrued liabilities and other current 
  liabilities                                  127,892       173,832       25,203 
 Customer deposits                                 972         1,803          261 
 Short-term borrowing                            2,370             -            - 
 Current portion of operating lease 
  liabilities                                   34,999        37,236        5,399 
 Total current liabilities                     372,184       411,451       59,655 
                                          ------------  ------------  ----------- 
 Non-current liabilities: 
 Non-current portion of operating lease 
  liabilities                                   49,316        13,551        1,965 
 Other non-current liabilities                  11,776         4,124          598 
 Total non-current liabilities                  61,092        17,675        2,563 
                                          ------------  ------------  ----------- 
 TOTAL LIABILITIES                             433,276       429,126       62,218 
                                          ============  ============  =========== 
 
   Shareholders' equity: 
 Class A ordinary shares                           116           117           17 
 Class B ordinary shares                            21            21            3 
 Additional paid-in capital                  4,280,956     4,582,790      664,442 
 Treasury stock                                      -      (58,919)      (8,542) 
 Accumulated deficits                      (2,228,713)   (3,199,946)    (463,949) 
 Accumulated other comprehensive loss        (207,069)     (165,722)     (24,027) 
 Total shareholders' equity                  1,845,311     1,158,341      167,944 
                                          ------------  ------------  ----------- 
 TOTAL LIABILITIES AND SHAREHOLDERS' 
  EQUITY                                     2,278,587     1,587,467      230,162 
                                          ============  ============  =========== 
 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Cash Flows

(in thousands)

 
                                                  For the three months ended 
                                              December      December     December 
                                              31, 2021      31, 2022      31, 2022 
                                          ---------------  ----------  ------------ 
                                                RMB            RMB          US$ 
 Net cash used in operating activities          (112,349)    (67,707)       (9,817) 
 Net cash used in investing activities           (66,970)     (5,033)         (730) 
 Net cash used in financing activities            (6,781)    (10,074)       (1,461) 
 Effect of exchange rate on cash, cash 
  equivalents and restricted cash                (24,498)     (5,924)         (859) 
 Net decrease in cash, cash equivalents 
  and restricted cash                           (210,598)    (88,738)      (12,867) 
 Cash, cash equivalents and restricted 
  cash at the beginning of period               1,649,710   1,014,006       147,018 
 Cash, cash equivalents and restricted 
  cash at the end of period                     1,439,112     925,268       134,151 
 
 
 
 
                                                        For the year ended 
                                                 December    December    December 
                                                 31, 2021     31, 2022    31, 2022 
                                               -----------  ----------  ---------- 
                                                   RMB          RMB         US$ 
 Net cash used in operating activities           (477,886)   (456,808)    (66,231) 
 Net cash generated from (used in) investing 
  activities                                        81,697     (7,463)     (1,082) 
 Net cash used in financing activities            (52,899)    (86,238)    (12,503) 
 Effect of exchange rate on cash, cash 
  equivalents and restricted cash                 (37,006)      36,665       5,316 
 Net decrease in cash, cash equivalents 
  and restricted cash                            (486,094)   (513,844)    (74,500) 
 Cash, cash equivalents and restricted 
  cash at the beginning of period                1,925,206   1,439,112     208,651 
 Cash, cash equivalents and restricted 
  cash at the end of period                      1,439,112     925,268     134,151 
 

Burning Rock Biotech Limited

Reconciliations of GAAP and Non-GAAP Results

 
                                                 For the three months ended 
                         --------  -----------------------------------------------------  -----------  ---------- 
                                               September    December    March      June     September    December 
                           March      June        30,         31,        31,       30,         30,         31, 
                            31 ,      30,        2021                    2022      2022       2022         2022 
                            2021      2021                    2021 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
                                                           (RMB in thousands) 
 Gross profit: 
 Central laboratory 
  channel                  55,212    58,681       58,387      65,985    50,574    57,575       69,991      54,507 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 In-hospital channel       20,070    29,426       31,111      34,194    33,396    20,012       31,593      26,999 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Pharma research and 
  development channel       1,658     2,124        2,098       5,200     3,610     5,015        7,010      19,757 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Total gross profit        76,940    90,231       91,596     105,379    87,580    82,602      108,594     101,263 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Add: depreciation 
  and amortization: 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Central laboratory 
  channel                     117       284        1,254         995     2,553     2,545        3,138       3,609 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 In-hospital channel           79       113          109         130        93     1,428        2,479       2,449 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Pharma research and 
  development channel          10        40           19         856     2,493     4,327        2,805       3,065 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Total depreciation 
  and amortization 
  included in cost 
  of revenues                 206       437        1,382       1,981     5,139     8,300        8,422       9,123 
 Non-GAAP gross profit 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Central laboratory                                                                                         58,11 
  channel                  55,329    58,965       59,641      66,980    53,127    60,120       73,129           6 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 In-hospital channel       20,149    29,539       31,220      34,324    33,489    21,440       34,072      29,448 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Pharma research and                                                                                        22,82 
  development channel       1,668     2,164        2,117       6,056     6,103     9,342        9,815           2 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Total non-GAAP gross 
  profit                   77,146    90,668       92,978     107,360    92,719    90,902      117,016     110,386 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Non-GAAP gross margin 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Central laboratory                                                                                           80. 
  channel                   74.2%     73.7%        75.7%       77.9%     71.6%     76.5%        81.3%         8 % 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 In-hospital channel        69.5%     72.9%        71.4%       66.1%     68.4%     62.7%        68.6%       69.2% 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Pharma research and 
  development channel       54.4%     31.9%        51.8%       64.0%     49.4%     51.7%        65.4%       82.3% 
                         --------  --------  -----------  ----------  --------  --------  -----------  ---------- 
 Total non-GAAP gross 
  margin                    72.4%     71.2%        73.4%       72.9%     68.4%     69.5%        75.7%       77.6% 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 

Burning Rock Biotech Limited

Reconciliations of GAAP and Non-GAAP Results

 
                                                                              For the year ended 
                                                                    -------------------------------------- 
                                                                     December 31, 2021   December 31, 2022 
                                                                    ------------------  ------------------ 
                                                                              (RMB in thousands) 
                                                                                      RMB 
 Gross profit: 
 Central laboratory channel                                                    238,265             232,647 
                                                                    ------------------  ------------------ 
 In-hospital channel                                                           114,801             112,000 
                                                                    ------------------  ------------------ 
 Pharma research and development channel                                        11,080              35,392 
                                                                    ------------------  ------------------ 
 Total gross profit                                                            364,146             380,039 
                                                                    ------------------  ------------------ 
 Add: depreciation and amortization: 
                                                                    ------------------  ------------------ 
 Central laboratory channel                                                      2,650              11,845 
                                                                    ------------------  ------------------ 
 In-hospital channel                                                               431               6,449 
                                                                    ------------------  ------------------ 
 Pharma research and development channel                                           925              12,690 
                                                                    ------------------  ------------------ 
 Total depreciation and amortization included in cost of revenues                4,006              30,984 
 Non-GAAP gross profit 
                                                                    ------------------  ------------------ 
 Central laboratory channel                                                    240,915            244,49 2 
                                                                    ------------------  ------------------ 
 In-hospital channel                                                           115,232             118,449 
                                                                    ------------------  ------------------ 
 Pharma research and development channel                                        12,005             48,0 82 
                                                                    ------------------  ------------------ 
 Total non-GAAP gross profit                                                   368,152             411,023 
 Non-GAAP gross margin 
                                                                    ------------------  ------------------ 
 Central laboratory channel                                                      75.4%               77.7% 
 In-hospital channel                                                             69.8%               67.6% 
 Pharma research and development channel                                         51.3%               65.7% 
 Total non-GAAP gross margin                                                     72.5%               73.0% 
 

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March 28, 2023 02:00 ET (06:00 GMT)

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