Bruker Introduces Novel NMR Scientific Capabilities for Structural Biology Discoveries in Membrane Proteins and Protein Aggregates
08 4월 2024 - 8:00PM
Business Wire
Bruker Corporation (Nasdaq: BRKR), the leading provider of
nuclear magnetic resonance (NMR) spectroscopy solutions, announces
the introduction of novel high-resolution solid-state NMR
scientific capabilities that can enable unprecedented structural
biology discoveries in large proteins, membrane proteins and in
protein aggregates.
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The rotor for the new CPMAS iProbe is 0.4
mm in diameter, rotating mechanically at 160kHz (pencil for scale)
(Photo: Business Wire)
At the 65th ENC (www.enc-conference.org), Bruker introduces a
new ultra-fast CP/MAS iProbe as the latest innovation in
solid-state NMR technology. Featuring a 160 kHz Magic Angle
Spinning (MAS) system, it takes high-resolution MAS and proton
detection on solid biological samples to the next level, enabling
new scientific discoveries. The dramatically enhanced 1H-NMR
resolution and enhanced T2' times make 160 kHz MAS suitable for the
study of large proteins, membrane proteins and protein aggregates.
Multiple 160 kHz MAS probes are available for customer
demonstrations and collaborations on 700 and 800 MHz NMR
spectrometers in Bruker’s applications facility in Germany. In
addition, a 160 kHz MAS probe is now installed on the 1.0 GHz NMR
at CNRS Lyon, where it expands the scientific capabilities of
biological solid-state research.
Professor Guido Pintacuda, CNRS researcher at the Institute of
Analytical Sciences in Lyon, commented: “With the new 160 kHz MAS
probe we witness a leap forward in resolution, now enabling us to
reveal the subtlest nuances of molecular structures and
interactions. This is a bold step into the atomic-level description
of biomolecules and will contribute to lift the role of NMR in
disease research to the next level.”
Bruker also introduces novel technology for standard-bore
(SB) DNP Probes for 600 and 800 MHz, and eventually for GHz SB
magnets to allow scientists to study small molecules, proteins or
materials with ultrahigh DNP-NMR sensitivity. The new SB-DNP probe
technology broadens the accessibility of solid-state DNP-NMR
research. Previously, wide-bore (WB) NMR magnets were required for
DNP, and now the same DNP-NMR sensitivity enhancements of 50x to
200x can be achieved with more economical and widely adopted SB NMR
magnets.
The new HCN SB DNP probes are available for LT-MAS below 100
Kelvin, with 1.3 mm or 0.7 mm MAS rotor diameters for
high-resolution MAS even at low temperatures. Bruker is in the
process of developing high-field gyrotrons for microwave
frequencies of 658 GHz to 790 GHz for solid-state DNP-NMR at 1.0
and 1.2 GHz.
About Bruker Corporation – Leader of the Post-Genomic Era
(Nasdaq: BRKR)
Bruker is enabling scientists and engineers to make breakthrough
post-genomic discoveries and develop new applications that improve
the quality of human life. Bruker’s high performance scientific
instruments and high value analytical and diagnostic solutions
enable scientists to explore life and materials at molecular,
cellular, and microscopic levels. In close cooperation with our
customers, Bruker is enabling innovation, improved productivity,
and customer success in post-genomic life science molecular and
cell biology research, in applied and biopharma applications, in
microscopy and nanoanalysis, as well as in industrial and cleantech
research, and next-gen semiconductor metrology in support of AI.
Bruker offers differentiated, high-value life science and
diagnostics systems and solutions in preclinical imaging, clinical
phenomics research, proteomics and multiomics, spatial and
single-cell biology, functional structural and condensate biology,
as well as in clinical microbiology and molecular diagnostics. For
more information, please visit www.bruker.com.
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version on businesswire.com: https://www.businesswire.com/news/home/20240408860289/en/
Investor Contact: Justin Ward Sr. Director, Investor
Relations & Corporate Development Bruker Corporation T: +1
(978) 313-5800 E: Investor.Relations@bruker.com
Media Contact: Markus Ziegler Sr. Director and Head of
Group Marketing Bruker BioSpin T: +49 172 3733531 E:
pr@bruker.com
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