RNS Number:2141K
Amersham PLC
22 April 2003



                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)         Name of company

           Amersham plc



2)         Name of shareholder having a major interest

           Franklin Resources Inc and its direct and indirect subsidiaries



3)         Please state whether notification indicates that it is in respect
of holding of the shareholder named in 2 above or in respect of a non-beneficial
interest or in the case of an individual holder if it is a holding of that
person's spouse or children under the age of 18

          
           Non Beneficial interest



4)        Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them


          Franklin Resources Inc and its direct and indirect subsidiaries


5)        Number of shares/amount of stock acquired

          Not advised



6)        Percentage of issued class

          N/A



7)        Number of shares/amount of stock disposed

          N/A



8)        Percentage of issued class

          N/A



9)        Class of security

          Ordinary shares of 5 pence each



10)       Date of transaction

          Not advised



11)       Date company informed

          21 April 2003



12)       Total holding following this notification

          35,764,410 Ordinary Shares of 5p each



13)       Total percentage holding of issued class following this notification

          5.0940%



14)       Any additional information

          N/A



15)       Name of contact and telephone number for queries

          Susan Henderson, Deputy Company Secretary Tel 01494 542063



16)       Name and signature of authorised company official responsible for
making this notification

           Susan M Henderson,





Date of notification 22 April 2003


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            The company news service from the London Stock Exchange
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