PTP Profile Thera.

The Alliance Trust PLC

Disclosure under Rules 8.1(a), 8.1(b)(I) and 8.3 of The City Code on Takeovers
and Mergers

Date of Disclosure                  1 April 2004
                                    
Date of Dealing                     31 March 2004
                                    
Dealing in                          Profile Therapeutics plc
                                    
1.  Class of Securities             Ordinary Shares
                                    
2.  Amount Bought         187,500
    Price per Unit                  50.0p
                                    
3.  Resultant total of the same     1,000,000    (2.03%)
    class owned or controlled
                                    
4.  Party making disclosure     The Alliance Trust PLC
                                    
5.  Name of Purchaser               Allsec Nominees Limited on
                                    behalf of The Alliance Trust
                                    PLC and The Second Alliance
                                    Trust PLC
                                    
6.  Reason for disclosure           The Alliance Trust PLC and The
                                    Second Alliance Trust PLC
                                    together own 2.03% of the
                                    equity and are deemed to be a
                                    single person for the purpose
                                    of Rule 8.
                                    
             Rule 8.3 (disclosure because
                                    of ownership or control of 1%
                                    or more of the class of
                                    relevant securities dealt in).

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