Pall Mustang Chromatography Speeds Virus Removal, Saving Time and Cost of Drug Development

     
BW20021211002337  20021211T170117Z UTC


( BW)(PALL-CORPORATION)(PLC) Pall Mustang Chromatography Speeds
Virus Removal, Saving Time and Cost of Drug Development

    Business Editors
    UK REGULATORY NEWS

    NEW ORLEANS, La.--(BUSINESS WIRE)--Dec. 11, 2002--

New data demonstrating how Pall Corporation (NYSE:PLL) Mustang(R)
membrane chromatography technology speeds virus removal and improves
safety of drug production were presented at the annual Parenteral Drug
Association meeting here today.

The technology ensures viral clearance at an extremely high
throughput, which can significantly speed purification processes and
accelerate the pace of new drug development. Mustang units are
disposable, enabling biopharmaceutical companies to reduce
manufacturing costs by eliminating cleaning and cleaning validation.

Economical production of new drugs requires innovative manufacturing
processes and a shift is taking place in the industry from permanent
to disposable production equipment. Disposable products eliminate the
time and considerable costs associated with dismantling and cleaning
equipment between batches. Pall is at the center of this growing trend
with the widest range of disposable filtration and purification
products on the market.

"Mustang chromatography is an innovative method of virus removal that
ensures the safety of new drug products, while significantly reducing
processing costs and time," says Sam Nochumson, Ph.D., Senior Manager
of Pall's Biopurification Laboratory. "Its high dynamic capacity
offers up to 100 times greater processing flow rates and eliminates
cleaning validation, a huge headache for manufacturers." Mustang
chromatography can potentially save manufacturers up to 200 days of
process development time.

Dr. Nochumson presented data demonstrating how Mustang ion exchange
technology removes an array of viruses through charged membranes. In
performance tests, over 7 logs of Porcine Parvovirus (PRV) were
removed in one processing pass, a significant technical achievement.
There were also dramatic log reductions for a range of other
pathogens, including retroviruses (HIV and Murine Leukemia Virus),
Hepatitis A (HAV), and Pseudorabies (PRV). These test organisms
represent the variety of large and small, enveloped and nonenveloped
viruses, that can destroy production runs that may be valued at
several thousand dollars per milligram.

"Traditional chromatography has limited application for large-scale
viral clearance because of its relatively low capacity, and long
residence times," says Tim N. Warner, Ph.D., Senior Manager, Process
Development and Biopurification at Pall. "Employing membrane ion
exchange technology, Mustang chromatography offers manufacturers a
viable new method of high throughput viral clearance that is
disposable and extremely convenient for scaling up."

About Pall Corporation

Pall Corporation is the global leader in the rapidly growing field of
filtration, separations and purification. Pall's business is organized
around two broad markets: Life Sciences and Industrial. The Company
provides leading-edge products to meet the demanding needs of
customers in biotechnology, pharmaceuticals, transfusion medicine,
semiconductors, municipal drinking water and aerospace. Total revenues
are $1.3 billion. The company is headquartered in East Hills, New
York, and has operations in more than 30 countries. Further
information can be found on its Web site http://www.pall.com.

    Note to Editor: Photo available upon request. Please contact
Patrice Radowitz.

   Short Name: Pall Corporation
   Category Code: MSC
   Sequence Number: 00001408
   Time of Receipt (offset from UTC): 20021211T163232+0000

    --30--jgm/in

    CONTACT: Pall Corporation
             Patrice Radowitz, 516/801-9104 
             Pat_Radowitz@pall.com

    KEYWORD: LOUISIANA NEW YORK UNITED KINGDOM INTERNATIONAL EUROPE
    INDUSTRY KEYWORD: BIOTECHNOLOGY MEDICAL MEDICAL DEVICES
PHARMACEUTICAL
    SOURCE: Pall Corporation

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