TIDMAZM 
 
RNS Number : 3345T 
Alizyme PLC 
04 June 2009 
 
+-----------------------------------------------+------------------------------------------------------------------+ 
| For immediate release                         |                                                      4 June 2009 | 
+-----------------------------------------------+------------------------------------------------------------------+ 
 
                                  ALIZYME PLC 
 
+------------------+---------------------------------------------------------------------------------------------+ 
| TR - 1:          | NOTIFICATION OF MAJOR INTERESTS IN SHARES                                                   | 
+------------------+---------------------------------------------------------------------------------------------+ 
 
+---------------------+---------------------+-+-------------+-+--------+-+-+---------------------+-+-+-------------+-------------+-+-+------------+----------------+------+-+-------------+ 
| 1. Identity of the issuer or the underlying issuer of existing                                                                 | Alizyme plc                                            | 
| shares to which voting rights are attached: ii                                                                                 |                                                        | 
+--------------------------------------------------------------------------------------------------------------------------------+--------------------------------------------------------+ 
| 2 Reason for the notification (please tick the appropriate box or boxes):                                                                                                               | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| An acquisition or disposal of voting rights                                                                                                                               | No          | 
+---------------------------------------------------------------------------------------------------------------------------------------------------------------------------+-------------+ 
| An acquisition or disposal of qualifying financial instruments which may result                                                                                           | No          | 
| in the acquisition of shares already issued to which voting rights are attached                                                                                           |             | 
+---------------------------------------------------------------------------------------------------------------------------------------------------------------------------+-------------+ 
| An acquisition or disposal of instruments with similar economic effect to                                                                                                 | No          | 
| qualifying financial instruments                                                                                                                                          |             | 
+---------------------------------------------------------------------------------------------------------------------------------------------------------------------------+-------------+ 
| An event changing the breakdown of voting rights                                                                                                                          | No          | 
+---------------------------------------------------------------------------------------------------------------------------------------------------------------------------+-------------+ 
| Other (please specify):                     | Changes to disclosure requirements                                                                                          | Yes         | 
+---------------------------------------------+-----------------------------------------------------------------------------------------------------------------------------+-------------+ 
| 3. Full name of person(s) subject to the                                                         | Gartmore Investment Limited                                                          | 
| notification obligation: iii                                                                     |                                                                                      | 
+--------------------------------------------------------------------------------------------------+--------------------------------------------------------------------------------------+ 
| 4. Full name of shareholder(s) (if different from                                                | Equities                                                                             | 
| 3.):iv                                                                                           |                                                                                      | 
|                                                                                                  | HSBC Global Custody Nominee UK Ltd                                                   | 
|                                                                                                  | 8,726,452 shares (3.947%)                                                            | 
|                                                                                                  |                                                                                      | 
|                                                                                                  | Nortrust Nominees Limited                                                            | 
|                                                                                                  | 8,150,388 shares (3.686%)                                                            | 
|                                                                                                  |                                                                                      | 
|                                                                                                  | Gartmore Growth Opportunities                                                        | 
|                                                                                                  | 2,349,203 shares (1.063%)                                                            | 
|                                                                                                  |                                                                                      | 
|                                                                                                  | BNY GIL CLT Account Nominees Ltd                                                     | 
|                                                                                                  | 7,897,268 shares (3.572%)                                                            | 
|                                                                                                  |                                                                                      | 
|                                                                                                  | Contract for Difference                                                              | 
|                                                                                                  |                                                                                      | 
|                                                                                                  | Vidacos Nominees Ltd A/C 2303                                                        | 
|                                                                                                  | 22,049,534 shares (9.973%)                                                           | 
|                                                                                                  |                                                                                      | 
+--------------------------------------------------------------------------------------------------+--------------------------------------------------------------------------------------+ 
| 5. Date of the transaction and date on which the                                                 | 1 June 2009                                                                          | 
| threshold is crossed or reached: v                                                               |                                                                                      | 
+--------------------------------------------------------------------------------------------------+--------------------------------------------------------------------------------------+ 
| 6. Date on which issuer notified:                                                                | 3 June 2009                                                                          | 
+--------------------------------------------------------------------------------------------------+--------------------------------------------------------------------------------------+ 
| 7. Threshold(s) that is/are crossed or                                                           | 22%                                                                                  | 
| reached: vi, vii                                                                                 |                                                                                      | 
+--------------------------------------------------------------------------------------------------+--------------------------------------------------------------------------------------+ 
| 8. Notified details:                                                                                                                                                                    | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| A: Voting rights attached to shares viii, ix                                                                                                                                            | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| Class/type of       | Situation previous to                              | Resulting situation after the triggering                                                                     | 
| shares              | the triggering                                     | transaction                                                                                                  | 
| if possible using   | transaction                                        |                                                                                                              | 
| the ISIN CODE       |                                                    |                                                                                                              | 
+                     +----------------------------------------------------+--------------------------------------------------------------------------------------------------------------+ 
|                     | Number of Shares                      | Number     | Number                                | Number of voting                              | %                    | 
|                     |                                       | of         | of                                    | rights                                        | of                   | 
|                     |                                       | Voting     | shares                                |                                               | voting               | 
|                     |                                       | Rights     |                                       |                                               | rights               | 
|                     |                                       |            |                                       |                                               | x                    | 
+                     +                                       +            +---------------------------------------+-----------------------------------------------+----------------------+ 
|                     |                                       |            | Direct                                | Direct xi       | Indirect xii                | Direct | Indirect    | 
+---------------------+---------------------------------------+------------+---------------------------------------+-----------------+-----------------------------+--------+-------------+ 
| Ordinary Shares     | 26,724,669                            | 26,724,669 | 27,123,311                            |                 | 27,123,311                  |        | 12.268%     | 
| GBP 0.02            |                                       |            |                                       |                 |                             |        |             | 
| GB0000374289        |                                       |            |                                       |                 |                             |        |             | 
+---------------------+---------------------------------------+------------+---------------------------------------+-----------------+-----------------------------+--------+-------------+ 
|                                                                                                                                                                                         | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| B: Qualifying Financial Instruments                                                                                                                                                     | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| Resulting situation after the triggering transaction                                                                                                                                    | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| Type of financial instrument                              | Expiration | Exercise/ Conversion                                    | Number                               | % of voting   | 
|                                                           | date xiii  | Period xiv                                              | of                                   | rights        | 
|                                                           |            |                                                         | voting                               |               | 
|                                                           |            |                                                         | rights                               |               | 
|                                                           |            |                                                         | that                                 |               | 
|                                                           |            |                                                         | may be                               |               | 
|                                                           |            |                                                         | acquired                             |               | 
|                                                           |            |                                                         | if the                               |               | 
|                                                           |            |                                                         | instrument                           |               | 
|                                                           |            |                                                         | is                                   |               | 
|                                                           |            |                                                         | exercised/                           |               | 
|                                                           |            |                                                         | converted.                           |               | 
+-----------------------------------------------------------+------------+---------------------------------------------------------+--------------------------------------+---------------+ 
|                                                           |            |                                                         |                                      |               | 
+-----------------------------------------------------------+------------+---------------------------------------------------------+--------------------------------------+---------------+ 
|                                                                                                                                                                                         | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv,                                                                                           | 
| xvi                                                                                                                                                                                     | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| Resulting situation after the triggering transaction                                                                                                                                    | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| Type of financial                         | Exercise price           | Expiration              | Exercise/                     | Number         | % of voting                           | 
| instrument                                |                          | date xvii               | Conversion                    | of             | rights xix, xx                        | 
|                                           |                          |                         | period xviii                  | voting         |                                       | 
|                                           |                          |                         |                               | rights         |                                       | 
|                                           |                          |                         |                               | instrument     |                                       | 
|                                           |                          |                         |                               | refers to      |                                       | 
+-------------------------------------------+--------------------------+-------------------------+-------------------------------+----------------+---------------------------------------+ 
| CFD                                       |                          |                         |                               | 22,049,534     | Nominal                 | Delta       | 
+                                           +                          +                         +                               +                +-------------------------+-------------+ 
|                                           |                          |                         |                               |                | 9.973%                  |             | 
+-------------------------------------------+--------------------------+-------------------------+-------------------------------+----------------+-------------------------+-------------+ 
|                                                                                                                                                                                         | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| Total (A+B+C)                                                                                                                                                                           | 
+-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------+ 
| Number of voting rights                                                                            | Percentage of voting rights                                                        | 
+----------------------------------------------------------------------------------------------------+------------------------------------------------------------------------------------+ 
| 49,172,845                                                                                         | 22.240%                                                                            | 
+---------------------+---------------------+-+-------------+-+--------+-+-+---------------------+-+-+-------------+-------------+-+-+------------+----------------+------+-+-------------+ 
 
+----------------------------------------------------------+----------------+--------------------------------------+ 
| 9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are         | 
| effectively held, if applicable: xxi                                                                             | 
+------------------------------------------------------------------------------------------------------------------+ 
|                                                                                                                  | 
+------------------------------------------------------------------------------------------------------------------+ 
|                                                                                                                  | 
+------------------------------------------------------------------------------------------------------------------+ 
| Proxy Voting:                                                                                                    | 
+------------------------------------------------------------------------------------------------------------------+ 
| 10. Name of the proxy holder:                                             |                                      | 
+---------------------------------------------------------------------------+--------------------------------------+ 
| 11. Number of voting rights proxy holder will cease to hold:              |                                      | 
+---------------------------------------------------------------------------+--------------------------------------+ 
| 12. Date on which proxy holder will cease to hold voting rights:          |                                      | 
+---------------------------------------------------------------------------+--------------------------------------+ 
|                                                                                                                  | 
+------------------------------------------------------------------------------------------------------------------+ 
| 13. Additional information:                              |                                                       | 
+----------------------------------------------------------+-------------------------------------------------------+ 
| 14. Contact name:                                        | Nick Blech, Company Secretary                         | 
+----------------------------------------------------------+-------------------------------------------------------+ 
| 15. Contact telephone number:                            | +44 (0) 1223 896000                                   | 
+----------------------------------------------------------+----------------+--------------------------------------+ 
 
 
 
 
This information is provided by RNS 
            The company news service from the London Stock Exchange 
   END 
 
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Alizyme (LSE:AZM)
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Alizyme (LSE:AZM)
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