News Summary:
- Delivers up to 2x[i] higher oligonucleotide
recovery from biofluids with improved LC-MS sensitivity and
reproducibility to support robust quantitation.
- Faster time-to-results for expanded range of bioanalysis
projects enabled through enhanced LC-MS sensitivity, and
standardized protocols that reduce method development and sample
processing time.
- Simplifies laborious sample preparation workflows, improves
robustness and repeatability, addresses poor/inconsistent
recoveries, while enabling greater MS sensitivity, accuracy, and
precision.
MILFORD, Mass., Oct. 19, 2023 /PRNewswire/ -- Waters Corporation
(WAT:NYSE) announces the launch of OligoWorks™ SPE (solid phase
extraction) Kits and components to improve sample preparation for
LC-MS-based bioanalytical quantitation of therapeutic
oligonucleotides. Pharma and biopharma companies developing
oligonucleotide therapeutics and the Contract Research
Organizations (CROs) that support them can now realize up to a
2x[i] increase over competing products in
oligonucleotide recovery from biofluids. The Kits deliver greater
reproducibility and LC-MS sensitivity, enabling lower limits of
quantitation and reducing the need for repeat experiments.
The pipeline for oligonucleotide therapeutics is rapidly
expanding with thirteen FDA approved oligonucleotide therapeutics
today, and 500+ in the pipeline. While potent, these highly
modified oligonucleotides are challenging to precisely quantify
during dosing, metabolism, and tissue distribution studies.
"As a leader in supporting drug development, Waters is committed
to solving customer pain points, and enabling greater analytical
performance and productivity. Our new OligoWorks SPE Kits directly
address oligonucleotide bioanalysis sample prep challenges across
diverse oligo therapeutics," said Erin
Chambers, Vice President, Consumables and Lab Automation,
Waters Corporation. "The science and societal effects of these
therapies are exploding given their ability to address human health
issues. Our workflow and kits will drive an acceleration of oligo
bioanalysis projects and drug development timelines; ultimately
improving the experience for drug candidates."
OligoWorks SPE Kits also use an innovative, enzyme-enhanced, and
detergent-free sample pretreatment that reduces washing steps and
improves mass spectrometer compatibility, thus enabling direct
injection LC-MS analysis and lower limits of quantitation. They can
also be fully automated for improved productivity, or to simply
help scientists gain back time by reducing manual steps and
oversight.
Available immediately, OligoWorks SPE Kits and components are
another high-performance tool within the growing portfolio of
Waters chemistry solutions to support oligonucleotide bioanalysis.
They complement Waters best-selling MaxPeak™ Premier Columns,
ACQUITY™ Premier LC System and Arc™ Premier LC System, Andrew+™
Pipetting Robot, and the class-leading sensitivity of the Waters
Xevo™ TQ Absolute Mass Spectrometer.
Additional Resources
- Learn more at: www.waters.com/OligoWorks
- Register for our Bioanalysis Zone webinar featuring
OligoWorks SPE Kits
- Waters OligoWorks SPE Kit application notes:
- An Automated, Standardized, Kit-Based Sample Preparation
Workflow for Bioanalytical Quantification of Therapeutic
Oligonucleotides
- Development of a Standardized, Kit-Based Approach for
Selective and Reproducible Sample Preparation and Extraction of
Therapeutic Oligonucleotides from Biological
Matrices
- Follow and connect with Waters via LinkedIn, Twitter, and
Facebook
About Waters Corporation (www.waters.com)
Waters Corporation (NYSE:WAT), a global leader in analytical
instruments and software, has pioneered chromatography, mass
spectrometry, and thermal analysis innovations serving the life,
materials, and food sciences for over 60 years. With approximately
8,000 employees worldwide, Waters operates directly in 35
countries, including 14 manufacturing facilities, and with products
available in more than 100 countries.
Waters, OligoWorks, MaxPeak, ACQUITY, Arc, Andrew+, and
Xevo are trademarks of Waters Corporation.
Contact:
Janice Foley
Senior Public Relations Manager, Corporate Communications
Waters Corporation
janice_foley@waters.com
Mobile: +1.617.823.5555
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[i] Based on head-to-head comparisons
against the major competitor demonstrating OligoWorks SPE Kits with
an increased recovery by more than 2x.
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