Zila Demonstrates Effectiveness of Photosensitizing Agent in Animal Model
24 10월 2008 - 1:30AM
Business Wire
Zila, Inc. (NASDAQ:ZILAD) today announced encouraging preliminary
results of an in vivo animal study which showed evidence of
photodestruction of premalignant lesions and squamous cell
carcinoma when treated with Zila�s patented pharmaceutical grade
toluidine blue, both a diagnostic adjuvant and a photosensitizer
for DMBA-induced precancers and cancers in the hamster cheek pouch
model. Squamous cell carcinoma is the most common form of oral,
cervical and, esophageal cancers. �We are extremely encouraged by
the results of these first animal tests,� said Dr. Mark Bride, Vice
President of Medical Affairs for Zila. �These results confirm that
a topical application of our toluidine blue, rather than the
traditional systemic administration of a photosensitizer and its
attendant side effects, may provide an effective alternative to
current PDT modalities. Additionally, we are encouraged by the
single treatment results with the Zila photosensitizer when
compared to the 4 to 8 treatments that are required for lesion
resolution with other photosensitizers. Longitudinal studies are
still needed to determine treatment prognoses.� The long-term goal
of the study conducted at the University of California, Irvine �
Beckman Laser Institute was to develop a photodynamic approach to
early detection, diagnosis and eradication of oral dysplasia and
malignancy. The specific aim of the study was to evaluate the
phototherapeutic effects of the Zila photosensitizer in the hamster
carcinogenesis model for various grades of pathology. About
Photodynamic Therapy (PDT) PDT is a treatment, and sometimes a
pre-treatment, that utilizes a substance called a photosensitizer
and specific wavelengths of light to activate the photosensitizer.
The light penetrates the tissue and causes excitation of the
photosensitizer. Once activated, an oxygen species of a higher
energy state is formed thus producing cytotoxic effects on target
cells and their structures. PDT cancer therapy has been approved by
the FDA for the treatment of esophageal cancer and non-small cell
lung cancer under certain circumstances. Researchers are currently
recruiting patients to study the applications for PDT in the
treatment of brain, skin, prostate, cervix, intestinal, stomach and
liver cancer. About Zila, Inc. Zila, Inc., headquartered in
Phoenix, Arizona, is a diagnostic company dedicated to the
prevention, detection and treatment of oral cancer and periodontal
disease. Zila manufactures and markets ViziLite� Plus with TBlue�
(�ViziLite� Plus�), the company�s flagship product for the early
detection of oral abnormalities that could lead to cancer.
ViziLite� Plus is an adjunctive medical device cleared by the FDA
for use in a population at increased risk for oral cancer. In
addition, Zila designs, manufactures and markets a suite of
proprietary products sold exclusively and directly to dental
professionals for periodontal disease, including the Rotadent�
Professional Powered Brush, the Pro-Select Platinum� ultrasonic
scaler and a portfolio of oral pharmaceutical products for both
in-office and home-care use. All of Zila�s products are marketed
and sold in the United States and Canada primarily through the
company�s direct field sales force and telemarketing organization.
The company�s products are marketed and sold in other international
markets through the direct sales forces of third party
distributors. Zila�s marketing programs reach most U.S. dental
offices and include continuing education seminars for dentists and
their staffs. This press release contains forward-looking
statements within the meaning of Section 27A of the Securities Act
of 1933 and Section 21E of the Securities Exchange Act of 1934.
These forward-looking statements are based largely on Zila's
expectations or forecasts of future events, can be affected by
inaccurate assumptions and are subject to various business risks
and known and unknown uncertainties, a number of which are beyond
the Company's control. Therefore, actual results could differ
materially from the forward-looking statements contained herein. A
wide variety of factors could cause or contribute to such
differences and could adversely affect revenue, profitability, cash
flows and capital needs. There can be no assurance that the
forward-looking statements contained in this press release will, in
fact, transpire or prove to be accurate. For a more detailed
description of these and other cautionary factors that may affect
Zila's future results, please refer to Zila's Form 10-K for its
fiscal year ended July 31, 2008. For more information about the
company and its products, please visit www.zila.com.
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