UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

     
Date of Report (Date of Earliest Event Reported):   March 21, 2008

Encysive Pharmaceuticals Inc.
__________________________________________
(Exact name of registrant as specified in its charter)

     
Delaware 0-20117 13-3532643
_____________________
(State or other jurisdiction
_____________
(Commission
______________
(I.R.S. Employer
of incorporation) File Number) Identification No.)
      
4848 Loop Central Drive, Suite 700, Houston, Texas   77081
_________________________________
(Address of principal executive offices)
  ___________
(Zip Code)
     
Registrant’s telephone number, including area code:   713-796-8822

Not Applicable
______________________________________________
Former name or former address, if changed since last report

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

[  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
[  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
[  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
[  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))


Item 2.02 Results of Operations and Financial Condition.

Encysive Pharmaceuticals Inc. (the "Company") previously reported the filing of its annual report on Form 10-K for the year ended December 31, 2007. This filing is available for review on the Company's website at www.encysive.com or on the Securities and Exchange Commission’s website at www.sec.gov.

As required under Nasdaq Marketplace Rule 4350(b)(1)(B), on March 21, 2008, the Company announced that its independent auditor’s report included in the annual report on Form 10-K contains a statement relating to their substantial doubt about the Company's ability to continue as a going concern.






SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

         
    Encysive Pharmaceuticals Inc.
          
March 24, 2008   By:   /s/ Richard A. Goeggel
       
        Name: Richard A. Goeggel
        Title: Vice President, Finance
Encysive Pharmaceuticals (MM) (NASDAQ:ENCY)
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