Aspect Medical Systems Announces Publication of BRITE-MD Trial Results in Psychiatry Research

Aspect Medical Systems, Inc. (NASDAQ: ASPM) today announced that two companion articles highlighting results from the BRITE-MD (Biomarkers for Rapid Identification of Treatment Effectiveness trial in Major Depression) were published in the September issue of the journal Psychiatry Research. The BRITE trial results demonstrate that Aspect’s EEG-based Antidepressant Treatment Response (ATR) indicator is a significant predictor of patient response and remission after one week of treatment with the commonly prescribed antidepressant escitalopram. Retrospective analysis of BRITE data also suggests that ATR has the potential to positively impact depression treatment outcomes by helping clinicians select the most effective antidepressant for each patient early in their treatment.

“The publication of BRITE trial results is a major milestone in our efforts to develop clinically useful biomarkers for predicting treatment response in Major Depressive Disorder. The BRITE results demonstrate that early changes in frontal EEG may help predict treatment outcome in as short a time as one week after the start of medication. We are hopeful that these results will be replicated by other researchers, and that an EEG biomarker can be used to help clinicians improve the care of patients suffering from depression,” said Andrew Leuchter, M.D., professor of Psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA, principal investigator for the trial, and chair of Aspect’s Neuroscience Advisory Board.

The BRITE trial was conducted in collaboration with leading investigators from nine facilities across the United States and enrolled 375 patients. Patient response was defined by researchers as a 50 percent improvement in depression symptoms as measured by the Hamilton Depression Rating Scale (HAM-D) after seven weeks of treatment, and remission was defined as recovery from depression (HAM-D

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