DALLAS, TX today announced record financial and operational results for the first quarter ended March 31, 2008. Highlights include:

--  Reported a quarterly profit of $521 thousand in net income, or $0.03
    per diluted share, resulting in three consecutive quarters of profit
    growth.

--  Achieved $11.5 million in revenue for the quarter, a record 407% rise
    in revenues for Q1 2008 compared to Q1 2007, representing four quarters
    of sequential revenue growth.

--  Attained gross margins of approximately 15% compared to 7% in Q1 2007,
    reflecting continued leverage of the Company's fixed cost
    infrastructure.

--  Generated EBITDA, as adjusted, of $784 thousand for the quarter.

      - EBITDA, as adjusted, (a non-GAAP measure) is defined as income
        (loss) from operations less depreciation and amortization, non-cash
        warrant and option compensation expense and executive severance.
        EBITDA, as adjusted, should be considered in addition to, but not
        in lieu of, income (loss) from operations reported under generally
        accepted accounting principles (GAAP).

--  The Company finished the quarter with $5.9 million in cash on hand and
    generated $1.6 million in cash from operating activities in the first
    quarter, the largest cash flow volume in the Company's history.

--  Claims volume increased to approximately 60 thousand for Q1 2008, up
    278% over Q1 2007.

--  Recent key executive additions:

      - Matthew Thompson appointed to Controller and Chief Accounting
        Officer.

Commenting on today's announcement, David S. Boone, Chief Executive Officer of American CareSource, stated, "We are very pleased to report such strong quarterly financial results. With renewed focus, we have now developed the most comprehensive national network of ancillary healthcare services providers in the country and, as a result, we are bringing our clients a wider range of services with highly favorable economics. We continue to deliver real cost savings to our clients and are demonstrating the value of our business model.

"The tremendous surge in revenues for the first quarter and the dramatic improvement in profitability compared to the same period of 2007, is a continuation of the trend we began last year and reflect both organic growth as well as the addition of several new clients during the past year. Given where we stand today and taking into account expected new client wins, further expansion of our provider network and growth in current client business, we continue to believe that the Company is on track to exceed its initial guidance of $50 million in revenues for the full year."

Revenues for the first quarter of 2008 rose 407% to $11.5 million compared to $2.3 million in the first quarter of 2007. The Company's first quarter revenues also represent a 14% improvement over fourth quarter 2007 reported revenues of $10.1 million.

The Company reported net income of $521 thousand, or $0.03 per diluted share, for the first quarter of 2008, compared to a net loss of $611 thousand, or $0.04 per share, in the same period last year. Factors affecting positive current quarter results include increases in revenue from the addition of five new clients which began with the Company in 2007 and the expansion of services for existing clients.

Cash provided by operations was $1.6 million in the first quarter of 2008 versus negative $546 thousand in the first quarter of 2007. Factors affecting the improvement in operating cash flows include earnings growth, accelerated client collections and overall effectiveness in working capital management. At March 31, 2008, the Company had $5.9 million in cash and cash equivalents compared to $4.3 million at December 31, 2007.

Conference Call

As previously announced, American CareSource will hold a conference call to discuss financial results of the first quarter ended March 31, 2008 as follows:

Date:  Thursday, May 15, 2008
Time:  10:00 a.m. (CT)/11:00 a.m. (ET)
Dial-in numbers: 877-675-4757 (U.S. & Canada) or 719-325-4911
Live webcast: www.anci-care.com, under "New & Events"

The teleconference replay will be available two hours after completion through Thursday, May 22, 2008 at 888-203-1112 (U.S. & Canada) or 719-457-0820. The replay pass code is 6620406. The archived webcast will be available for one year on the Company's investor website, www.anci-care.com, under "News and Events."

About American CareSource Holdings, Inc.

American CareSource Holdings, the first national, publicly traded ancillary care network services company, offers a comprehensive national network of more than 25,000 ancillary provider sites. Through its product offerings, American CareSource helps its clients reduce the cost of ancillary services rendered through its network of providers in more than 30 service categories. The Company's ancillary network and management provides a complete outsourced solution for a wide variety of healthcare payors and plan sponsors including self-insured employers, indemnity insurers, PPOs, HMOs, third party administrators and both federal and local governments.

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995:

Any statements that are not historical facts contained in this release are forward-looking statements. It is possible that the assumptions made by American CareSource Holdings, Inc. for purposes of such statements may not materialize. Actual results may differ materially from those projected or implied in any forward-looking statements. Such statements may involve further risks and uncertainties, including but not limited to those relating to product demand, pricing, market acceptance, the effect of economic conditions, and intellectual property rights, and the outcome of competitive products, risks in product development, the ability to complete transactions, and other risks identified in this release, and the Securities and Exchange Commission filings of American CareSource Holdings, Inc.

American CareSource Holdings, Inc.
Balance Sheet (unaudited)
March 31, 2008 and December 31, 2007

                                                  March 31,   December 31,
                                                    2008          2007
ASSETS
Current Assets
Cash                                            $  5,857,094  $  4,272,498
Accounts receivable, net                           3,248,579     3,651,203
Prepaids and Other Current Assets                    427,195       409,445
                                                ------------  ------------
Total Current Assets                               9,532,868     8,333,146

Net Property, Plant and Equipment                    388,504       332,450

Other Assets
Certificate of Deposit, restricted                   145,000       145,000
Other Non-Current Assets                             420,238       492,977
Intangible Assets                                  1,440,843     1,494,238
Goodwill                                           4,361,299     4,361,299
                                                ------------  ------------
Total Other Assets                                 6,367,380     6,493,514
                                                ------------  ------------

TOTAL ASSETS                                    $ 16,288,752  $ 15,159,110
                                                ============  ============

LIABILITIES
Current Liabilities
Due to Service Providers                        $  3,709,889  $  3,344,278
Accounts Payable and Accrued Liabilities           1,288,963     1,320,036
Current Maturities of Long-Term Debt                  56,697        55,697
                                                ------------  ------------
Total Current Liabilities                          5,055,549     4,720,011

Long-Term Debt                                        35,784        50,348

TOTAL LIABILITIES                                  5,091,333     4,770,359

EQUITY
Common Stock                                         150,674       146,684
Preferred Stock-par value $0.01, 10,000,000
 shares authorized and none outstanding                    -             -
Additional Paid In Capital - General              17,897,140    17,613,880
Accumulated Deficit                               (6,850,395)   (7,371,813)
                                                ------------  ------------

TOTAL EQUITY                                      11,197,419    10,388,751
                                                ------------  ------------

TOTAL LIABILITIES AND EQUITY                    $ 16,288,752  $ 15,159,110
                                                ============  ============




American CareSource Holdings, Inc.
Consolidated Statements of Operations (unaudited)
                                                    Three months ended
                                                  3/31/2008     3/31/2007
                                                ------------  ------------

Net Revenues                                    $ 11,505,675  $  2,266,569

Total Cost of Revenues                             9,801,122     2,101,643
                                                ------------  ------------

Contribution Margin                                1,704,553       164,926


Selling General and Administrative Expense         1,112,854       694,421
Depreciation and Amortization                         92,067        78,074
                                                ------------  ------------

Total Operating Expenses                           1,204,921       772,495

Operating Income (Loss)                              499,632      (607,569)
                                                ------------  ------------

Interest Income                                      (40,668)      (53,874)
Interest Expense                                       1,838        11,071
Debt Issuance Cost                                         -        46,300
                                                ------------  ------------

Total Other (Income) Expenses                        (38,830)        3,497

Net Income (Loss) Before Income Taxes                538,462      (611,066)
Income Tax Provision                                  17,044             -
                                                ------------  ------------

Net Income (Loss)                               $    521,418  $   (611,066)
                                                ============  ============


Earnings (loss) per common share:
  Basic                                         $       0.04  $      (0.04)
  Diluted                                       $       0.03  $      (0.04)

Weighted average common shares outstanding:

  Basic                                           14,880,266    14,486,749

  Diluted                                         17,255,201    14,486,749





American CareSource Holdings, Inc.
Statement Of Cash Flows (unaudited)
One Month and Three Months Ended March 31, 2008


                                                Three Months  Three Months
                                                    Ended         Ended
                                                  3/31/2008     3/31/2007
                                                ------------  ------------
Cash flows from operating activities
Net Income/(Loss)                               $    521,418  $   (611,066)

Adjustments to Reconcile Net Loss to Net Cash
Used In Operating Activities:
    Stock-based Compensation Expense                 157,525        49,536
    Depreciation/Amortization                         92,067        78,074
    Debt issuance costs                                    -        46,300
    Client Management Expense Related to
     Warrants                                         13,228             -
    Changes In operating Assets and
     Liabilities:
      Accounts Receivable                            402,624       384,844
      Prepaids and Other Assets                       41,761       (25,660)
      Accounts Payable and Accrued Liabilities       (31,073)      (22,287)
      Due to Service Providers                       365,611      (445,683)
                                                ------------  ------------

Net Cash Provided by/(Used In) Operating
 Activities                                        1,563,161      (545,942)
                                                ------------  ------------

Cash flows from Investing activities
Purchases and Development of Property and
 Equipment                                           (94,726)      (18,833)
                                                ------------  ------------

Net Cash Used In Investing Activities                (94,726)      (18,833)
                                                ------------  ------------


Cash flows from financing activities
Payments On Long Term Debt                           (13,564)     (309,659)
Net Proceeds from the Exercise of Stock Options      129,725         1,924
                                                ------------  ------------

Net Cash Provided By/(Used In) Financing
 Activities                                          116,161      (307,735)
                                                ------------  ------------

Net Increase/(Decrease) In Cash                    1,584,596      (872,510)
Cash At Beginning Of Period                        4,272,498     5,025,380
                                                ------------  ------------

Cash At End Of Period                           $  5,857,094  $  4,152,870
                                                ============  ============



American CareSource Holdings Inc.
Calculation of EBITDA and EBITDA, as adjusted (unaudited)
Three months ended March 31, 2008


                                                Three months  Three months
                                                ended March   ended March
                                                  31, 2008      31, 2007
                                                ------------- ------------

Operating income (loss)                         $     499,632 $   (607,569)

Depreciation and Amortization                          92,067       78,074
                                                ------------- ------------

EBITDA                                                591,699     (529,495)

Executive severance                                    21,844            -

Non-cash Option/Warrant Compensation Expense          170,753       49,536
                                                ------------- ------------

EBITDA, as adjusted                             $     784,296 $   (479,959)
                                                ============= ============

Contact: David S. Boone Chief Executive Officer American CareSource Holdings, Inc. Tel: 972-308-6830

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