Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

SABBY MANAGEMENT, LLC

2. Date of Event Requiring Statement (MM/DD/YYYY) 3/12/2018

3. Issuer Name and Ticker or Trading Symbol

Rosetta Genomics Ltd. [ROSG]

(Last) (First) (Middle)

10 MOUNTAINVIEW ROAD, SUITE 205

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director ___ X ___ 10% Owner
_____ Officer (give title below) _____ Other (specify below)

(Street)

UPPER SADDLE RIVER, NJ 07458

(City) (State) (Zip)

5. If Amendment, Date Original Filed (MM/DD/YYYY)

6. Individual or Joint/Group Filing (Check Applicable Line)

___ Form filed by One Reporting Person
_ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
ADR Shares (each one equal to 2 ordinary shares)	713230	I ⁽¹⁾ ⁽³⁾	See Footnotes ⁽¹⁾ ⁽³⁾

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
$598,000 Convertible Debenture due February 23, 2047 ⁽¹⁾ ⁽²⁾ ⁽³⁾	2/23/2017 ⁽²⁾	2/23/2047	ADR Shares ⁽²⁾	650000 ⁽²⁾	$0.92	I ⁽¹⁾ ⁽³⁾	See Footnotes ⁽¹⁾ ⁽²⁾ ⁽³⁾
$1,885,000 Convertible Debenture due October, 2047 ⁽¹⁾ ⁽²⁾ ⁽³⁾	10/2/2017 ⁽²⁾	10/2/2047	ADR Shares ⁽²⁾	2048913 ⁽²⁾	$0.92	I ⁽¹⁾ ⁽³⁾	See Footnotes ⁽¹⁾ ⁽²⁾ ⁽³⁾
$19.7567 Strike Warrant ⁽¹⁾ ⁽²⁾ ⁽³⁾	10/15/2015 ⁽²⁾	10/15/2020	ADR Shares ⁽²⁾	42970 ⁽²⁾	$19.7567	I ⁽¹⁾ ⁽³⁾	See Footnotes ⁽¹⁾ ⁽²⁾ ⁽³⁾
$0.92 Strike Warrant ⁽¹⁾ ⁽²⁾ ⁽³⁾	11/29/2016 ⁽²⁾	11/29/2021	ADR Shares ⁽²⁾	833334 ⁽²⁾	$0.92	I ⁽¹⁾ ⁽³⁾	See Footnotes ⁽¹⁾ ⁽²⁾ ⁽³⁾
$1.15 Strike Warrant ⁽¹⁾ ⁽²⁾ ⁽³⁾	10/2/2017 ⁽²⁾	10/2/2022	ADR Shares ⁽²⁾	2173912 ⁽²⁾	$1.15	I ⁽¹⁾ ⁽³⁾	See Footnotes ⁽¹⁾ ⁽²⁾ ⁽³⁾
$1.50 Strike Warrant ⁽¹⁾ ⁽²⁾ ⁽³⁾	8/9/2017 ⁽²⁾	8/9/2022	ADR Shares ⁽²⁾	1624623 ⁽²⁾	$1.5	I ⁽¹⁾ ⁽³⁾	See Footnotes ⁽¹⁾ ⁽²⁾ ⁽³⁾

Explanation of Responses:
(1)	This Form 3 is being filed by Sabby Healthcare Master Fund, Ltd. ("SHMF"), Sabby Volatility Warrant Master Fund, Ltd. ("SVWMF"), Sabby Management, LLC ("Advisor") and Hal Mintz. Advisor is the investment manager of SHMF and SVWMF. Mr. Mintz is the manager of Advisor.
(2)	The conversion or exercise of this security into shares is subject to a blocker, and the holder is not allowed to convert or exercise the security into shares if as a result of such conversion or exercise the holder (in the aggregate with its affiliates) would own in excess of 4.99% of the outstanding shares. As holder (in the aggregate with its affiliates) currently owns more than 4.99% of the outstanding shares, this security is not currently eligible for conversion or exercise into shares.
(3)	The amount reported herein reflects the entire amount of Issuer's securities held by SHMF and SVWMF as of March 12, 2018. Each of the Advisor and Mr. Mintz disclaims, for purposes of Section 16 of tthe Securities Exchange Act of 1934 ("Section 16"), beneficial ownership of such securities, except to the extent of its/his indirect pecuniary interest therein, and this report shall not be deemed an admission that either Advisor or Mr. Mintz is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
SABBY MANAGEMENT, LLC 10 MOUNTAINVIEW ROAD SUITE 205 UPPER SADDLE RIVER, NJ 07458		X
Sabby Healthcare Master Fund, Ltd. C/O SABBY MANAGEMENT, LLC 10 MOUNTAINVIEW ROAD, SUITE 205 UPPER SADDLE RIVER, NJ 07458		X

Signatures
/s/ Robert Grundstein, COO and General Counsel of Sabby Management, LLC		3/13/2018
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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