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Ocular Therapeutix Inc

Ocular Therapeutix Inc (OCUL)

6.94
0.00
(0.00%)
종가: 28 2월 6:00AM
6.94
0.00
( 0.00% )
시간외 거래: 8:00AM

행사 가격매수가매도가최근 가격중간 가격가격 변동가격 변동 %거래량미결제 약정최근 거래
2.500.000.000.000.000.000.00 %00-
5.001.752.202.351.9750.000.00 %056-
7.500.200.300.220.25-0.03-12.00 %2342,49605:18:47
10.000.020.050.050.0350.03150.00 %845103:54:08
12.500.050.050.050.050.000.00 %0296-
15.000.150.750.150.450.000.00 %0166-
17.500.000.000.000.000.000.00 %00-

포트폴리오 강화: 실시간 토론 및 실행 가능한 거래 아이디어.

행사 가격매수가매도가최근 가격중간 가격가격 변동가격 변동 %거래량미결제 약정최근 거래
2.500.000.750.000.000.000.00 %00-
5.000.000.000.000.000.000.00 %00-
7.500.000.000.000.000.000.00 %00-
10.000.000.000.000.000.000.00 %00-
12.500.000.000.000.000.000.00 %00-
15.007.709.504.678.600.000.00 %00-
17.500.000.000.000.000.000.00 %00-

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OCUL Discussion

게시물 보기
Whalatane Whalatane 23 시간 전
OT. suggest you look at APP at these levels . Short report is not credible .
Kiwi
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Whalatane Whalatane 2 주 전
Well I wish I could have got you , RMB and a few others into APP .
Huge move after hrs
Kiwi
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Number sleven Number sleven 2 주 전
Kiwi, Good luck to you as well.
Sleven,
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Whalatane Whalatane 2 주 전
N7. While there are many things I like about OCUL , if it starts trading below $7 it will start to trigger stop loss's I have in place.
Simple portfolio management .
Most of my biotechs are down ...and AI related software stocks ( PLTR, APP ) and cyber security stocks ( CRWD, CYBR ) are up .....so staying with strength and getting stopped out of weakness .
Good luck
Kiwi
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Number sleven Number sleven 3 주 전
Kiwi, That is Why I wanted to move from eypt to ocular. I expected the positive phase 2 study would give me the opportunity.
Sleven,
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Whalatane Whalatane 3 주 전
Cantor Fitzgerald (pre-mkt) reit'd $EYPT Overweight, says "there's nothing here that makes us less positive on the DME data/opportunity - if anything, it gives us higher confidence in the POS for a less clinically risky non-inferiority pivotal program:"
$OCUL $REGN $SRZN $XBI
TD Cowen reiterated $EYPT Buy-$20, says the 24-week benefit should still be enough to achieve Phase III success—and if the Phase III is successful with Q6M dosing, DME is a blockbuster opportunity that is not far off from wet AMD:


Cantor and Cowan still positive on EYPT . From a Quick Look at their trial ...small numbers and one patient that appeared to drop out then was " rescued " may have skewed results .
OCUL tho IMHO is further ahead , has a P 3 readout in Q4 with 1 fully enrolled P 3 trial and a second recruiting , their previous trials indicated benefit in DME and they have plenty of cash .
Some think they have the stronger drug
They also will have first mover advantage
JMO
Kiwi
👍️0
Whalatane Whalatane 3 주 전
BofA reiterated $OCUL Buy-$18-Top Small-Cap after its Meeting w/ MGMT in SF.
$EYPT $REGN

"We caught with $OCUL management to set expectations and discuss the strategic outlook for 2025. Management highlighted their continued focus on their registrational wet age-related macular degeneration (wAMD) program for Axpaxli.

Recall, Axpaxli is currently being evaluated in 2 complementary phase 3 studies, SOL-1 and SOL-R. SOL-1, which is evaluating single Axpaxli injection
versus a single injection of 2mg aflibercept, completed randomization in December 2024
with topline data expected to readout in 4Q25.

We reiterate our view that a positive readout is likely based on initial data supporting the long-term durability of Axpaxli in wAMD and the favorable trial design. On SOL-R, which is evaluating repeat Axpaxli
injections every 6 months versus 2mg aflibercept injections every eight weeks, management reported 311 patients have enrolled in the study as of January 10th, 2024 (enrollment initiated in November 2024).

They noted the trial was designed to help inform real-world treatment decisions. We are encouraged by the fast enrollment rate that we think reflects both the company's ability to clinically execute and the high unmet need for less frequently dosed treatment options.
Management commented they expect a positive SOL-1 readout would significantly de-risk SOL-R.

On the entry of aflibercept biosimilars, management said they do not see a direct impact to the commercial opportunity for Axpaxli given the differentiated dosing profile and value proposition.

We currently model $1.14bn in risk-adjusted peak sales for Axpaxli in wAMD contributing $13/sh to our PO.

While management emphasizes their primary focus is currently on wAMD, management highlighted they remain committed to expanding the opportunity in
other ophthalmology indications. They plan to meet with FDA in 1H25 on next steps for clinical study in non-proliferative diabetic retinopathy. They also highlighted that all patients in the HELIOS trial with diabetic macular edema (DME) showed signs of
improvement and they are exploring options in this indication as well.

We maintain our Buy with $18 PO and highlight $OCUL as our top small-cap pick for 2025.

We continue to be encouraged by Axpaxli's differentiated long-acting profile in wAMD with a potential first-to-market path ahead of competitor long-acting tyrosine kinase inhibitors."

Kiwi
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Whalatane Whalatane 3 주 전
N7. sorry to see that with EYPT. I saw the headline that it was a positive trial but apparently some questioned the data on digging deeper
Raymond James reiterated $OCUL Strong Buy-$19.
$REGN $SRZN $APLS
Raymond James said in its note to investors:
"Wednesday, before market open, EyePoint ( $EYPT, not covered ) released 6-month top-line results for the VERONA study of Duravyu in diabetic macular edema (DME).

In our view, the results were neutral to positive for the sustained release VEGFR TKI drug class within DME, but leave plenty of room for Ocular's Axpaxli to improve.

We note that Ocular does not currently have Axpaxli in clinical trials for DME, but has stated intent to pursue a broad development strategy in all indications where anti-VEGF therapies have proven effective.

In our view Axpaxli, which utilizes a more potent TKI axitinib (vs. vorolanib for Duravyu), holds the
advantage on durability and fluid reduction as evidenced by the relative efficacy in NPDR, which should translate well to DME.

OCUL hasn't been acting that great lately so I'm thinking about reducing my position ....need to do some DD
Raggy and RMB are in CADL which has data due this Qt . Hope it works for them .
I generally stay away from Oncology
Kiwi
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Number sleven Number sleven 3 주 전
Kiwi, Positive phase 2 results followed by a massive sell off completely fucked up my trading plan.
Sleven,
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Number sleven Number sleven 1 월 전
Kiwi, I focus on distressed assets. I am not sector focused. I am going to watch MPW until 2026.
Sleven,
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Whalatane Whalatane 1 월 전
Well on rereading that post I need clarify and note I've also owned some huge blow ups ....chk the 5 yr chart of QS.
Taken out 20-25% down from its high .
I try to adhere to a Marty Zweig principal ... "cut your loss's and let your winners run "...or something like that .
Good luck
Kiwi
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Number sleven Number sleven 1 월 전
Kiwi, Thanks for sharing your basic strategy.
Sleven,
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Whalatane Whalatane 1 월 전
N7. an example of disruptive tech ...SOUN.
I had reduced my position in the recent frenzy but will add back in tomorrow . I use voice activation whenever possible in my Tesla . When my son has his Spotify app running ....if you want to listen to Bob Marley music for instance ...you just press a button on the steering wheel and say ...play Bob Marley .
SOUN is mainly in fast food drive thru's and Lucid ...but once you start using it you can appreciate how it saves labor costs at drive thru's ...and ease of use in autos.

Kiwi
👍️0
Whalatane Whalatane 1 월 전
MPW ...is that a health care REIT ?
Not something I usually look at .
I mainly look for new disruptive business's / technologies
AMZN ...my biggest holding . Yes Bezos started selling books ...but you could see the wider applications . The only store I go into now ( besides Apple ) is the grocery store . Everything else ( clothes , shoes , toilet paper , tools etc etc ) is usually one day delivery on Amazon for me .
NFLX ...Last time I was in a movie theater was pre Covid ...Now everything is streamed via NFLX , Apple and Amazon
NVDA . I think I argued their case to you in early 2023 . Yes AI was making a lot of mistakes then but the amount of $ and talent going into that area you know it would eventually work . Any debate I have now is all sourced from Perplexity or ChatGPT
PLTR ...from early 2023 ..you could see their " boot camps " gaining traction .
More speculative .. APP ...my eldest son works for a media buying Co in LA ....driving sales thru Meta etc . APP appears to be disrupting part of that market

Then biotech where I may have some first hand experience ...or is in an area my wife deals with ( Kidney disease )

Those are the areas I generally stick to .
Happy to share ideas

Kiwi
👍️0
Number sleven Number sleven 1 월 전
Kiwi, I am no fan of biotech. Take a look at MPW. I'd be interested to hear what you think. This is a fairly dead board.
Sleven,
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Number sleven Number sleven 1 월 전
Kiwi, Same to you.
Sleven,
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Whalatane Whalatane 1 월 전
Most of my portfolio is long term holds ...like AMZN for over 10 yrs .
I do speculate in some areas of biotech and tech as you can see on " IHUB boards posted on " .......but thats 20% of my portfolio at most .
So I'm pretty risk adverse
EYPT looks more risk than OCUL ...in my layman analysis . It's down 17% in the past week . If it went below $6.8 I'd probably be out of it if I owned it ..
Re assessing / selling half on a 20-25 % individual stock pull back has saved my portfolio multiple times over the years .

There may be more upside in EYPT vs OCUL ...but its more risk then I want to take .

I'm more willing to take risk with ARDX and UNCY ( UNCY is very risky ) because my wife has patients on serum phosphorous drugs ...and most are no where near serum pho goal. She and the Nephrologists she works with want these drugs for their patients . Each of these have issues ...as you can see being discussed on those boards .
Good luck
Kiwi
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Number sleven Number sleven 1 월 전
Kiwi, Take a look at the share count for both companies.
Sleven,
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Number sleven Number sleven 1 월 전
Kiwi, I agree. I also don't want to spend time in another biotech while it launches a drug. If the eypt p2 trial is successful, (it should be) I intend switching to ocular. They should get a nice bump on p3 outcome. I Will leave and go back for the eypt p3.
What are your thoughts?
Sleven,
👍️0
Whalatane Whalatane 1 월 전
Thx for the link ... Saw Citi note
OCUL P 3 data Q4 2025
EYPT. P 3 data in 2026
Expects OCUL to be first to market ...efficacy skews towards EYPT while trial end pts skew towards OCUL ...expect both to meaningfully share in wAMD market with one eventually dominating .
I think OCUL will be submitting data from 2 P 3 trials ...so should have a smoother road to approval.
Dont know how much better EYPT's drug is ( based on data today ) vs OCUL ....but if close , first mover advantage for OCUL IMHO is huge

Kiwi
👍️0
Number sleven Number sleven 1 월 전
Kiwi,
https://www.biospace.com/press-releases/eyepoint-provides-company-update-and-anticipated-development-milestones-for-2025#:~:text=Positive%20interim%2016%2Dweek%20data,%2B8.9%20letters%20vs.%20baseline.
Sleven,
👍️0
Number sleven Number sleven 1 월 전
Kiwi, Thanks for the information.
Sleven,
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Whalatane Whalatane 1 월 전
N7. Someone U might want to follow on Biotech Values

Worstluck
# 254273
Tuesday, January 14, 2025 10:33:21 AM
Post# of 254288
EYPT

Looked at the slide deck for tonight's JPM and it notes the first P3 is about 1/3 enrolled and the second is "exceeding expectations." Pending color I take that as toplines around Oct and Dec 2026, subject to normal variance.
https://investors.eyepointpharma.com/static-files/09d5a2c6-310f-4820-8890-b6096ca41b3a slide 18

Getting a topline for the OCUL Sol-R trial is kind of tricky given no guidance, the long lead time between enrollment and randomization and allowing for some screen failures during that period. I can envision a topline in the same timeframe as EYPT (Q4 2026) +/- a month best/worst. Again, there are some assumptions built in.
👍️0
Whalatane Whalatane 1 월 전
N7. I'll do some more. DD as I have time this week . Thx for the analysis ...my energies been elsewhere last couple of days .
Re timing etc . Poster Chromosome on the AMRN board . He worked at ZS pharma and they were competing with RLYP for a new / better drug for treating high serum potassium in dialysis patients . High serum pot leads to heart arrhythmia's and heart attacks .

Anyway ...ZS Pharma's drug was slightly better than RLYP's drug ...but because their production facility was delayed in getting FDA approval .....RLYP's drug was first on the market .
Now RPYP's drug dominates as most ( including my wife who prescribes it ) are familiar with it , has the codes for ordering etc etc .
Pt being ...huge advantage for first mover ...and OCUL will likely be the first on the market assuming efficacy and safety in their final P3 trials .

To date OCUL's AXPAXLI is just as safe as Eyelea and 80% are " rescue free " out to 10 mths ...I'll chk EYPT's drug for comparison .
Feel free to find holes in my analysis . I'm wrong a lot ...cant afford to let any ego get in the way of correcting course when necessary .

Rosemouthbomber ( from AMRN ) is also in a number of other biotechs I'm in ...RZLT , UNCY and ARDX ...all with their own issues and catalysts in 2025

Kiwi
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Number sleven Number sleven 1 월 전
Kiwi, I think there might be a good play moving between the two companies. Thoughts?
Sleven,
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Number sleven Number sleven 1 월 전
Kiwi, Just to be clear, I don't care who has the better drug. In this case I'm only interested in market reaction and timing. Looking to go from eypt to ocular and back to eypt.
Sleven,
👍️0
Number sleven Number sleven 1 월 전
Kiwi, Stay safe. The acceleration of enrollment in the ocular wet-amd trials is why I'm thinking about trading. From what I have read I think the eye point drug is better. Doesn't actually matter to me. Looking for a shift from eypt to ocular after the phase 2 results.
Sleven,
👍️0
Whalatane Whalatane 1 월 전
N7. I had looked at EYPT but went with OCUL instead because of the team they had assembled , how fast the trials were enrolling , safety data etc .
OCUL will have the first pivotal P 3 trial data .....SOL-1 in Q4 2025 .
Their SOL-R trial now has 311 randomized ( I need to chk the total number they were aiming for ) . If both trials are successful they will file for approval to treat wet AMD .
Bottom line ....if all goes well they will have an approved drug well before EYPT.

Meanwhile this field is not standing still
VABYSMO seems to be the new eye drug of choice ...lasting 3-4 mths for 78 % of those getting this eye injection . OCUL's AXPAXLI is expected to last up to 10 mths .
My Kaiser eye doc tells me the biggest problem with Eyelea ( Afliberecept ) is most patients won't stick to the repeat dosing if they need an eye injection every 2-3 mths..
I think AXPAXL ( OCUL ) and Eyelea have similar safety profiles .
Its a long term hold for me .
Been distracted with other things recently ( clearing shrubs , brush from around my house , setting up fire suppression sprinklers etc ) I'm in Nth Ca and surround by trees . Area has a history of bad fires ...so everyone here is a little on edge after what happened in LA

Kiwi
👍️0
Number sleven Number sleven 1 월 전
Kiwi, I own eypt. Phase 2 trial ends this month. Should be positive. The phase 3 that ocular is running should also be positive. Based on the phase 1 results. Considering a trade.
Sleven,
👍️0
Whalatane Whalatane 1 월 전
Hi N7 I generally hold thru trial results and then " sell the news " if positive .
Launching new drugs usually takes more $ and longer then most expect
Company presentation scheduled on Monday, January 13th at 5:15 PM PT

Ocular to provide enrollment update for SOL-R, Ocular’s second registrational trial of AXPAXLI™ in wet AMD, future opportunities for AXPAXLI, and a general corporate overview

If you're interested in Co suggest you listen to the JPM presentation

Kiwi
👍️0
Number sleven Number sleven 2 월 전
Kiwi, long term investment, or a trade based on the upcoming clinical trial?
Sleven,
👍️0
Whalatane Whalatane 4 월 전
Scotiabank Initiates Coverage On Ocular Therapeutix with Sector Outperform Rating, Announces Price Target of $22

Kiwi
👍️0
Whalatane Whalatane 4 월 전
https://investors.ocutx.com/node/13236/pdf...trial enrolling ahead of schedule

Kiwi
👍️0
Whalatane Whalatane 5 월 전
As per the recent conference ...recruiting is going well and the speculation is that their trial will be fully enrolled ahead of schedule .
Eyelea ...the drug they will compete with ...is still increasing sales

Kiwi
👍️0
Whalatane Whalatane 8 월 전
Anybody out there ? Nice day to have a position in OCUL
Kiwi
👍️0
Whalatane Whalatane 11 월 전
OCUL. P2 data 4/5/24
REUTERS
10:03 AM ET 04/06/2024
April 6 (Reuters) - Ocular Therapeutix Inc (OCUL):
* OCULAR THERAPEUTIX™ ANNOUNCES POSITIVE PHASE 2 PAXTRAVA™ GLAUCOMA DATA AT THE AMERICAN SOCIETY OF CATARACT AND REFRACTIVE SURGERY 2024 ANNUAL MEETING
* OCULAR THERAPEUTIX INC (OCUL) - GENERALLY WELL TOLERATED WITH NO IMPACT ON CORNEAL HEALTH OBSERVED
* OCULAR THERAPEUTIX INC (OCUL) - CLINICALLY MEANINGFUL MEAN IOP REDUCTION OF ABOUT 24-30% FROM BASELINE OBSERVED OVER SIX MONTHS Source text for Eikon: Further company coverage:

Kiwi
👍️0
Monksdream Monksdream 11 월 전
OCUL under $10
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Monksdream Monksdream 12 월 전
OCUL 10Q due March 11
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glenn1919 glenn1919 1 년 전
OCUL....................................https://stockcharts.com/h-sc/ui?s=OCUL&p=W&b=5&g=0&id=p86431144783
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trendzone trendzone 2 년 전
Tard sells $6.00 call option at $0.15 at the close,apparently they were born yesterday.
👍️0
glenn1919 glenn1919 2 년 전
OCUL..........................................https://stockcharts.com/h-sc/ui?s=OCUL&p=W&b=5&g=0&id=p86431144783
👍️0
trendzone trendzone 2 년 전
Clueless fool sells $6.00 call option at $0.10 when they were just trading at $0.30,with the big rally going on in the stock today, what a total fool they are.
👍️0
cuggegrosse cuggegrosse 2 년 전
I chose OCUL to invest in because the market conditions should not effect the PPS(much),plus I can sell covered calls and make some monthly cash,besides they have products that are in demand !!!!
👍️ 1
cuggegrosse cuggegrosse 2 년 전
Yes I have noticed that
👍️ 1
Tzr250rg Tzr250rg 2 년 전
Ask is super thin wont take much to move. GLTUA
👍️0
cuggegrosse cuggegrosse 2 년 전
My eye doctor says Dextenza is a very good drug and he raccomends it !!!!!
👍️ 1
cuggegrosse cuggegrosse 2 년 전
DEXTENZA is doing very,very well,great revs expected in 2023
👍️ 1
cuggegrosse cuggegrosse 2 년 전
This company could go to $8.00 very eassy
👍️ 1
spotonge spotonge 2 년 전
boys need to wake up
👍️0
biotechslayr biotechslayr 2 년 전
Is anyone at all following OCUL into the end of the months binary? TKI data could be a game changer. Total TAM is ridiculous (look at REGN mcap!)
👍️ 1

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